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Showing 1 to 12 of 35 entries
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Characterization and functional analysis of the 5' flanking region of myosin light chain-2 gene expressed in white muscle of the gilthead sea bream (Sparus aurata).

Comparative biochemistry and physiology. Part D, Genomics & proteomics

Funkenstein B, Skopal T, Rapoport B, Rebhan Y, Du SJ, Radaelli G.
PMID: 20483292
Comp Biochem Physiol Part D Genomics Proteomics. 2007 Sep;2(3):187-99. doi: 10.1016/j.cbd.2007.04.001. Epub 2007 Apr 11.

The promoter region ( approximately 1400 bp) of myosin light chain 2 gene of fast skeletal muscle from the marine fish Sparus aurata was cloned, sequenced and characterized. It contains a consensus sequence for TATA box, six perfect E-boxes...

Differential Contribution of Transcription Factors to Arabidopsis thaliana Defense Against Spodoptera littoralis.

Frontiers in plant science

Schweizer F, Bodenhausen N, Lassueur S, Masclaux FG, Reymond P.
PMID: 23382734
Front Plant Sci. 2013 Feb 04;4:13. doi: 10.3389/fpls.2013.00013. eCollection 2013.

In response to insect herbivory, Arabidopsis plants activate the synthesis of the phytohormone jasmonate-isoleucine, which binds to a complex consisting of the receptor COI1 and JAZ repressors. Upon proteasome-mediated JAZ degradation, basic helix-loop-helix transcription factors (TFs) MYC2, MYC3, and...

TBX3 Promotes Melanoma Migration by Transcriptional Activation of ID1, which Prevents Activation of E-Cadherin by MITF.

The Journal of investigative dermatology

Peres J, Damerell V, Chauhan J, Popovic A, Desprez PY, Galibert MD, Goding CR, Prince S.
PMID: 33744299
J Invest Dermatol. 2021 Sep;141(9):2250-2260.e2. doi: 10.1016/j.jid.2021.02.740. Epub 2021 Mar 17.

In melanoma, a phenotype switch from proliferation to invasion underpins metastasis, the major cause of melanoma-associated death. The transition from radial to vertical growth phase (invasive) melanoma is characterized by downregulation of both E-cadherin (CDH1) and MITF and upregulation...

ID3 promotes homologous recombination via non-transcriptional and transcriptional mechanisms and its loss confers sensitivity to PARP inhibition.

Nucleic acids research

Bakr A, Hey J, Sigismondo G, Liu CS, Sadik A, Goyal A, Cross A, Iyer RL, Müller P, Trauernicht M, Breuer K, Lutsik P, Opitz CA, Krijgsveld J, Weichenhan D, Plass C, Popanda O, Schmezer P.
PMID: 34718742
Nucleic Acids Res. 2021 Nov 18;49(20):11666-11689. doi: 10.1093/nar/gkab964.

The inhibitor of DNA-binding 3 (ID3) is a transcriptional regulator that limits interaction of basic helix-loop-helix transcription factors with their target DNA sequences. We previously reported that ID3 loss is associated with mutational signatures linked to DNA repair defects....

Homodimeric and Heterodimeric Interactions among Vertebrate Basic Helix-Loop-Helix Transcription Factors.

International journal of molecular sciences

Torres-Machorro AL.
PMID: 34884664
Int J Mol Sci. 2021 Nov 28;22(23). doi: 10.3390/ijms222312855.

The basic helix-loop-helix transcription factor (bHLH TF) family is involved in tissue development, cell differentiation, and disease. These factors have transcriptionally positive, negative, and inactive functions by combining dimeric interactions among family members. The best known bHLH TFs are...

Characterization of muscle-regulatory genes, Myf5 and myogenin, from striped bass and promoter analysis of muscle-specific expression.

Marine biotechnology (New York, N.Y.)

Tan X, Hoang L, Du S.
PMID: 14961228
Mar Biotechnol (NY). 2002 Dec;4(6):537-45. doi: 10.1007/s10126-002-0013-1.

Myf5 and Myogenin are basic helix-loop-helix transcription factors that belong to the muscle regulatory factor (MRF) gene family, which plays important roles in regulating skeletal muscle development and growth. Members of the MRF family, including Myf5, MyoD, Myogenin, and...

Genomic Characterization and Expression Analysis of Basic Helix-Loop-Helix (bHLH) Family Genes in Traditional Chinese Herb .

Plants (Basel, Switzerland)

Wang Y, Liu A.
PMID: 32824436
Plants (Basel). 2020 Aug 17;9(8). doi: 10.3390/plants9081044.

No abstract available.

Genomics of the OLIG family of a bHLH transcription factor associated with oligo dendrogenesis.

Bioinformation

Choudhury S.
PMID: 31312081
Bioinformation. 2019 Jun 15;15(6):430-438. doi: 10.6026/97320630015430. eCollection 2019.

The glial cell neoplasms are not fully classified by using cellular morphology. However, this is possible using known molecular markers in glial development. Oligo-dendrocyte lineage gene induces differentiation of neural progenitors and putative immature progenitor cells of the adult...

ID4 mediates proliferation of astrocytes after excitotoxic damage in the mouse hippocampus.

Anatomy & cell biology

Lee YS, Kang JW, Lee YH, Kim DW.
PMID: 21829756
Anat Cell Biol. 2011 Jun;44(2):128-34. doi: 10.5115/acb.2011.44.2.128. Epub 2011 Jun 30.

Inhibitor of DNA binding (ID) proteins bind to and inhibit the function of basic helix-loop-helix transcription factors, including those that regulate proliferation and differentiation during development. However, little is known about the role of ID proteins in glial activation...

PHYTOCHROME INTERACTING FACTOR1 Enhances the E3 Ligase Activity of CONSTITUTIVE PHOTOMORPHOGENIC1 to Synergistically Repress Photomorphogenesis in Arabidopsis.

The Plant cell

Xu X, Paik I, Zhu L, Bu Q, Huang X, Deng XW, Huq E.
PMID: 24858936
Plant Cell. 2014 May;26(5):1992-2006. doi: 10.1105/tpc.114.125591. Epub 2014 May 23.

CONSTITUTIVE PHOTOMORPHOGENIC1 (COP1) is a RING/WD40 repeat-containing ubiquitin E3 ligase that is conserved from plants to humans. COP1 forms complexes with SUPPRESSOR OF PHYTOCHROME A (SPA) proteins, and these complexes degrade positively acting transcription factors in the dark to...

Introducing Pitt-Hopkins syndrome-associated mutations of TCF4 to Drosophila daughterless.

Biology open

Tamberg L, Sepp M, Timmusk T, Palgi M.
PMID: 26621827
Biol Open. 2015 Nov 30;4(12):1762-71. doi: 10.1242/bio.014696.

Pitt-Hopkins syndrome (PTHS) is caused by haploinsufficiency of Transcription factor 4 (TCF4), one of the three human class I basic helix-loop-helix transcription factors called E-proteins. Drosophila has a single E-protein, Daughterless (Da), homologous to all three mammalian counterparts. Here...

A classification of basic helix-loop-helix transcription factors of soybean.

International journal of genomics

Hudson KA, Hudson ME.
PMID: 25763382
Int J Genomics. 2015;2015:603182. doi: 10.1155/2015/603182. Epub 2015 Feb 11.

The complete genome sequence of soybean allows an unprecedented opportunity for the discovery of the genes controlling important traits. In particular, the potential functions of regulatory genes are a priority for analysis. The basic helix-loop-helix (bHLH) family of transcription...

Showing 1 to 12 of 35 entries