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[The effect of experimental extrahepatic cholestasis on absorption, distribution and elimination of digoxin].

Annales Academiae Medicae Stetinensis

Wójcicki M.
PMID: 9199126
Ann Acad Med Stetin. 1996;42:51-65.

Clinical observations indicate an increased number of post-operative complications and deaths in jaundiced patients. The patient may require some simultaneous treatment of concomitant ailments, among which cardiovascular diseases occur rather frequently. Some of the drugs administered then, like digoxin,...

[Effect of a new low-cholesterol meat and vegetal product on correction of simulated lipid metabolism disorders in rats].

Voprosy pitaniia

Gorlov IF, Slozhenkina MI, Karpenko EV, Giro TM, Andreeva SV.
PMID: 26402947
Vopr Pitan. 2015;84(1):80-8.

The paper presents the biomedical evaluation of meat and cereal spread from low-cholesterol raw material with vegetable ingredients, recommended as a functional food. The experimental model with myocardial infarction like changes in hearts of the animals, accompanied by vascular...

Ascites and alpha-fetoprotein improve prognostic performance of Barcelona Clinic Liver Cancer staging.

World journal of gastroenterology

Gomaa AI, Al-Khatib A, Abdel-Razek W, Hashim MS, Waked I.
PMID: 25987792
World J Gastroenterol. 2015 May 14;21(18):5654-62. doi: 10.3748/wjg.v21.i18.5654.

AIM: To assess how ascites and alpha-fetoprotein (AFP) added to the Barcelona Clinic Liver Cancer (BCLC) staging predict hepatocellular carcinoma survival.METHODS: The presence of underlying cirrhosis, ascites and encephalopathy, Child-Turcotte-Pugh (CTP) score, the number of nodules, and the maximum...

Involvement of cyclooxygenase-2 in the potentiation of allyl alcohol-induced liver injury by bacterial lipopolysaccharide.

Toxicology and applied pharmacology

Ganey PE, Barton YW, Kinser S, Sneed RA, Barton CC, Roth RA.
PMID: 11446826
Toxicol Appl Pharmacol. 2001 Jul 15;174(2):113-21. doi: 10.1006/taap.2001.9183.

Bacterial endotoxin (lipopolysaccharide; LPS) augments the hepatotoxicity of a number of xenobiotics including allyl alcohol. The mechanism for this effect is known to involve the inflammatory response elicited by LPS. Upregulation of cyclooxygenase-2 (COX-2) and production of eicosanoids are...

Immuno- and hepato-toxicity of dichloroacetic acid in MRL(+/+) and B(6)C(3)F(1) mice.

Journal of immunotoxicology

Cai P, Boor PJ, Khan MF, Kaphalia BS, Ansari GA, Konig R.
PMID: 18958719
J Immunotoxicol. 2007 Apr;4(2):107-15. doi: 10.1080/15476910701337225.

Dichloroacetic acid (DCA) is a by-product of chlorination that occurs in drinking water disinfected with chlorine. Metabolism of trichloroethene (TCE) also generates DCA. TCE exposure is associated with the development of autoimmune diseases, which may be induced by TCE...

Encorafenib, binimetinib plus pembrolizumab triplet therapy in patients with advanced BRAF.

European journal of cancer (Oxford, England : 1990)

Zimmer L, Livingstone E, Krackhardt A, Schultz ES, Göppner D, Assaf C, Trebing D, Stelter K, Windemuth-Kieselbach C, Ugurel S, Schadendorf D.
PMID: 34655839
Eur J Cancer. 2021 Oct 13;158:72-84. doi: 10.1016/j.ejca.2021.09.011. Epub 2021 Oct 13.

BACKGROUND: Combination of immune checkpoint inhibitors and mitogen-activated protein kinase (MAPK) pathway inhibitors (MAPKi) has been proposed to enhance the durability of anti-tumour responses induced by MAPKi. Here, we present phase I safety results from an open-label, phase I/II...

Long-term toxicity and carcinogenicity studies of cake made from chlorinated flour. 1. Studies in rats.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Fisher N, Hutchinson JB, Berry R, Hardy J, Ginocchio AV.
PMID: 6684624
Food Chem Toxicol. 1983 Aug;21(4):427-34. doi: 10.1016/0278-6915(83)90098-4.

Wistar rats were fed for 104 wk on cake-based diets in which the cake, prepared from unchlorinated flour, or flour treated with 1250 or 2500 ppm chlorine, formed 79% of the diet on a 12.6% moisture basis. A fourth...

Potential effects of dietary seaweeds mixture on the growth performance, antioxidant status, immunity response, and resistance of striped catfish (Pangasianodon hypophthalmus) against Aeromonas hydrophila infection.

Fish & shellfish immunology

Abdelhamid AF, Ayoub HF, Abd El-Gawad EA, Abdelghany MF, Abdel-Tawwab M.
PMID: 34601138
Fish Shellfish Immunol. 2021 Dec;119:76-83. doi: 10.1016/j.fsi.2021.09.043. Epub 2021 Oct 01.

Striped catfish (Pangasianodon hypophthalmus) is one of the important fish species in the world, which is widely cultured in several countries worldwide including Egypt. Aeromonas hydrophila infection showed a high prevalence in the farmed striped catfish negatively affecting its...

The clinical host response to microbial infection in medical patients with fever.


Bossink AW, Groeneveld AB, Hack CE, Thijs LG.
PMID: 10453866
Chest. 1999 Aug;116(2):380-90. doi: 10.1378/chest.116.2.380.

STUDY OBJECTIVES: Predictors among demographic, clinical, and laboratory variables for a microbial (nonviral/nonchlamydial) infection in hospitalized medical patients with new onset of fever (temperature > or =38.0 degrees C axillary or > or =38.3 degrees C rectal) were analyzed...

Long-term dutasteride therapy in men with benign prostatic hyperplasia alters glucose and lipid profiles and increases severity of erectile dysfunction.

Hormone molecular biology and clinical investigation

Traish A, Haider KS, Doros G, Haider A.
PMID: 28632494
Horm Mol Biol Clin Investig. 2017 Jun 21;30(3). doi: 10.1515/hmbci-2017-0015.

Background Dutasteride has been successfully used in treatment of lower urinary tract symptoms (LUTS) secondary to benign prostatic hyperplasia (BPH). However, dutasteride inhibits 5α-reductase type 1 and type 2 enzymes and may compromises glucocorticoids and androgen metabolism and alters...

Structures of Escherichia coli histidinol-phosphate aminotransferase and its complexes with histidinol-phosphate and N-(5'-phosphopyridoxyl)-L-glutamate: double substrate recognition of the enzyme.


Haruyama K, Nakai T, Miyahara I, Hirotsu K, Mizuguchi H, Hayashi H, Kagamiyama H.
PMID: 11294630
Biochemistry. 2001 Apr 17;40(15):4633-44. doi: 10.1021/bi002769u.

Histidinol-phosphate aminotransferase (HspAT) is a key enzyme on the histidine biosynthetic pathway. HspAT catalyzes the transfer of the amino group of L-histidinol phosphate (Hsp) to 2-oxoglutarate to form imidazole acetol phosphate (IAP) and glutamate. Thus, HspAT recognizes two kinds...

Activity of enzymes of carbon metabolism during the induction of Crassulacean acid metabolism in Mesembryanthemum crystallinum L.


Holtum JA, Winter K.
PMID: 24271620
Planta. 1982 Jun;155(1):8-16. doi: 10.1007/BF00402925.

The maximum extractable activities of twenty-one photosynthetic and glycolytic enzymes were measured in mature leaves of Mesembryanthemum crystallinum plants, grown under a 12 h light 12 h dark photoperiod, exhibiting photosynthetic characteristics of either a C3 or a Crassulacean...

Showing 1 to 12 of 30367 entries