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Immuno- and hepato-toxicity of dichloroacetic acid in MRL(+/+) and B(6)C(3)F(1) mice.

Journal of immunotoxicology

Cai P, Boor PJ, Khan MF, Kaphalia BS, Ansari GA, Konig R.
PMID: 18958719
J Immunotoxicol. 2007 Apr;4(2):107-15. doi: 10.1080/15476910701337225.

Dichloroacetic acid (DCA) is a by-product of chlorination that occurs in drinking water disinfected with chlorine. Metabolism of trichloroethene (TCE) also generates DCA. TCE exposure is associated with the development of autoimmune diseases, which may be induced by TCE...

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Cai P, Boor PJ, Khan MF, et al. Immuno- and hepato-toxicity of dichloroacetic acid in MRL(+/+) and B(6)C(3)F(1) mice. J Immunotoxicol. 2007;4(2):107-15doi: 10.1080/15476910701337225.
Cai, P., Boor, P. J., Khan, M. F., Kaphalia, B. S., Ansari, G. A., & Konig, R. (2007). Immuno- and hepato-toxicity of dichloroacetic acid in MRL(+/+) and B(6)C(3)F(1) mice. Journal of immunotoxicology, 4(2), 107-15. https://doi.org/10.1080/15476910701337225
Cai, Ping, et al. "Immuno- and hepato-toxicity of dichloroacetic acid in MRL(+/+) and B(6)C(3)F(1) mice." Journal of immunotoxicology vol. 4,2 (2007): 107-15. doi: https://doi.org/10.1080/15476910701337225
Cai P, Boor PJ, Khan MF, Kaphalia BS, Ansari GA, Konig R. Immuno- and hepato-toxicity of dichloroacetic acid in MRL(+/+) and B(6)C(3)F(1) mice. J Immunotoxicol. 2007 Apr;4(2):107-15. doi: 10.1080/15476910701337225. PMID: 18958719.
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Encorafenib, binimetinib plus pembrolizumab triplet therapy in patients with advanced BRAF.

European journal of cancer (Oxford, England : 1990)

Zimmer L, Livingstone E, Krackhardt A, Schultz ES, Göppner D, Assaf C, Trebing D, Stelter K, Windemuth-Kieselbach C, Ugurel S, Schadendorf D.
PMID: 34655839
Eur J Cancer. 2021 Oct 13;158:72-84. doi: 10.1016/j.ejca.2021.09.011. Epub 2021 Oct 13.

BACKGROUND: Combination of immune checkpoint inhibitors and mitogen-activated protein kinase (MAPK) pathway inhibitors (MAPKi) has been proposed to enhance the durability of anti-tumour responses induced by MAPKi. Here, we present phase I safety results from an open-label, phase I/II...

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Zimmer L, Livingstone E, Krackhardt A, et al. Encorafenib, binimetinib plus pembrolizumab triplet therapy in patients with advanced BRAF. Eur J Cancer. 2021;158:72-84doi: 10.1016/j.ejca.2021.09.011.
Zimmer, L., Livingstone, E., Krackhardt, A., Schultz, E. S., Göppner, D., Assaf, C., Trebing, D., Stelter, K., Windemuth-Kieselbach, C., Ugurel, S., & Schadendorf, D. (2021). Encorafenib, binimetinib plus pembrolizumab triplet therapy in patients with advanced BRAF. European journal of cancer (Oxford, England : 1990), 15872-84. https://doi.org/10.1016/j.ejca.2021.09.011
Zimmer, Lisa, et al. "Encorafenib, binimetinib plus pembrolizumab triplet therapy in patients with advanced BRAF." European journal of cancer (Oxford, England : 1990) vol. 158 (2021): 72-84. doi: https://doi.org/10.1016/j.ejca.2021.09.011
Zimmer L, Livingstone E, Krackhardt A, Schultz ES, Göppner D, Assaf C, Trebing D, Stelter K, Windemuth-Kieselbach C, Ugurel S, Schadendorf D. Encorafenib, binimetinib plus pembrolizumab triplet therapy in patients with advanced BRAF. Eur J Cancer. 2021 Oct 13;158:72-84. doi: 10.1016/j.ejca.2021.09.011. Epub 2021 Oct 13. PMID: 34655839.
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Potential effects of dietary seaweeds mixture on the growth performance, antioxidant status, immunity response, and resistance of striped catfish (Pangasianodon hypophthalmus) against Aeromonas hydrophila infection.

Fish & shellfish immunology

Abdelhamid AF, Ayoub HF, Abd El-Gawad EA, Abdelghany MF, Abdel-Tawwab M.
PMID: 34601138
Fish Shellfish Immunol. 2021 Dec;119:76-83. doi: 10.1016/j.fsi.2021.09.043. Epub 2021 Oct 01.

Striped catfish (Pangasianodon hypophthalmus) is one of the important fish species in the world, which is widely cultured in several countries worldwide including Egypt. Aeromonas hydrophila infection showed a high prevalence in the farmed striped catfish negatively affecting its...

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Abdelhamid AF, Ayoub HF, Abd El-Gawad EA, et al. Potential effects of dietary seaweeds mixture on the growth performance, antioxidant status, immunity response, and resistance of striped catfish (Pangasianodon hypophthalmus) against Aeromonas hydrophila infection. Fish Shellfish Immunol. 2021;119:76-83doi: 10.1016/j.fsi.2021.09.043.
Abdelhamid, A. F., Ayoub, H. F., Abd El-Gawad, E. A., Abdelghany, M. F., & Abdel-Tawwab, M. (2021). Potential effects of dietary seaweeds mixture on the growth performance, antioxidant status, immunity response, and resistance of striped catfish (Pangasianodon hypophthalmus) against Aeromonas hydrophila infection. Fish & shellfish immunology, 11976-83. https://doi.org/10.1016/j.fsi.2021.09.043
Abdelhamid, Ahmed F, et al. "Potential effects of dietary seaweeds mixture on the growth performance, antioxidant status, immunity response, and resistance of striped catfish (Pangasianodon hypophthalmus) against Aeromonas hydrophila infection." Fish & shellfish immunology vol. 119 (2021): 76-83. doi: https://doi.org/10.1016/j.fsi.2021.09.043
Abdelhamid AF, Ayoub HF, Abd El-Gawad EA, Abdelghany MF, Abdel-Tawwab M. Potential effects of dietary seaweeds mixture on the growth performance, antioxidant status, immunity response, and resistance of striped catfish (Pangasianodon hypophthalmus) against Aeromonas hydrophila infection. Fish Shellfish Immunol. 2021 Dec;119:76-83. doi: 10.1016/j.fsi.2021.09.043. Epub 2021 Oct 01. PMID: 34601138.
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Activity of enzymes of carbon metabolism during the induction of Crassulacean acid metabolism in Mesembryanthemum crystallinum L.

Planta

Holtum JA, Winter K.
PMID: 24271620
Planta. 1982 Jun;155(1):8-16. doi: 10.1007/BF00402925.

The maximum extractable activities of twenty-one photosynthetic and glycolytic enzymes were measured in mature leaves of Mesembryanthemum crystallinum plants, grown under a 12 h light 12 h dark photoperiod, exhibiting photosynthetic characteristics of either a C3 or a Crassulacean...

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Holtum JA, Winter K. Activity of enzymes of carbon metabolism during the induction of Crassulacean acid metabolism in Mesembryanthemum crystallinum L. Planta. 1982;155(1):8-16doi: 10.1007/BF00402925.
Holtum, J. A., & Winter, K. (1982). Activity of enzymes of carbon metabolism during the induction of Crassulacean acid metabolism in Mesembryanthemum crystallinum L. Planta, 155(1), 8-16. https://doi.org/10.1007/BF00402925
Holtum, J A, and Winter, K. "Activity of enzymes of carbon metabolism during the induction of Crassulacean acid metabolism in Mesembryanthemum crystallinum L." Planta vol. 155,1 (1982): 8-16. doi: https://doi.org/10.1007/BF00402925
Holtum JA, Winter K. Activity of enzymes of carbon metabolism during the induction of Crassulacean acid metabolism in Mesembryanthemum crystallinum L. Planta. 1982 Jun;155(1):8-16. doi: 10.1007/BF00402925. PMID: 24271620.
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The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis.

Journal of clinical and diagnostic research : JCDR

Cakir OO, Toker A, Ataseven H, Demir A, Polat H.
PMID: 28571184
J Clin Diagn Res. 2017 Apr;11(4):OC17-OC21. doi: 10.7860/JCDR/2017/24958.9621. Epub 2017 Apr 01.

INTRODUCTION: Acute hepatitis is acute inflammation of liver elicited by a large number of causes. It sometimes spontaneously recovers, sometimes may progress to chronic hepatitis. Liver- Fatty Acid Binding Protein (L-FABP) is a small protein that is abundant in...

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Cakir OO, Toker A, Ataseven H, et al. The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis. J Clin Diagn Res. 2017;11(4):OC17-OC21doi: 10.7860/JCDR/2017/24958.9621.
Cakir, O. O., Toker, A., Ataseven, H., Demir, A., & Polat, H. (2017). The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis. Journal of clinical and diagnostic research : JCDR, 11(4), OC17-OC21. https://doi.org/10.7860/JCDR/2017/24958.9621
Cakir, Ozlem Ozer, et al. "The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis." Journal of clinical and diagnostic research : JCDR vol. 11,4 (2017): OC17-OC21. doi: https://doi.org/10.7860/JCDR/2017/24958.9621
Cakir OO, Toker A, Ataseven H, Demir A, Polat H. The Importance of Liver-Fatty Acid Binding Protein in Diagnosis of Liver Damage in Patients with Acute Hepatitis. J Clin Diagn Res. 2017 Apr;11(4):OC17-OC21. doi: 10.7860/JCDR/2017/24958.9621. Epub 2017 Apr 01. PMID: 28571184; PMCID: PMC5449830.
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Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells.

Annals of translational medicine

Xue R, Qiu J, Wei S, Liu M, Wang Q, Wang P, Sha B, Wang H, Shi Y, Zhou J, Rao J, Lu L.
PMID: 33987329
Ann Transl Med. 2021 Apr;9(8):631. doi: 10.21037/atm-20-7084.

BACKGROUND: Lycopene is a naturally occurring carotenoid found in many fruits and vegetables, which has antioxidant effects. Although lycopene's protective effect has been observed on ischemia reperfusion (IR) injury in different organs, the effect of lycopene on Kupffer cells...

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Xue R, Qiu J, Wei S, et al. Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells. Ann Transl Med. 2021;9(8):631doi: 10.21037/atm-20-7084.
Xue, R., Qiu, J., Wei, S., Liu, M., Wang, Q., Wang, P., Sha, B., Wang, H., Shi, Y., Zhou, J., Rao, J., & Lu, L. (2021). Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells. Annals of translational medicine, 9(8), 631. https://doi.org/10.21037/atm-20-7084
Xue, Rong, et al. "Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells." Annals of translational medicine vol. 9,8 (2021): 631. doi: https://doi.org/10.21037/atm-20-7084
Xue R, Qiu J, Wei S, Liu M, Wang Q, Wang P, Sha B, Wang H, Shi Y, Zhou J, Rao J, Lu L. Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells. Ann Transl Med. 2021 Apr;9(8):631. doi: 10.21037/atm-20-7084. PMID: 33987329; PMCID: PMC8106004.
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Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes.

Toxics

Resiere D, Kallel H, Oxybel O, Chabartier C, Florentin J, Brouste Y, Gueye P, Megarbane B, Mehdaoui H.
PMID: 32283693
Toxics. 2020 Apr 09;8(2). doi: 10.3390/toxics8020028.

The epidemiology of severe acute poisonings in the French overseas departments of the Americas remains poorly reported. The main objective of this study was to determine the epidemiology and characteristics of severe acutely poisoned adult patients.METHODS: A retrospective descriptive...

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Resiere D, Kallel H, Oxybel O, et al. Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes. Toxics. 2020;8(2)doi: 10.3390/toxics8020028.
Resiere, D., Kallel, H., Oxybel, O., Chabartier, C., Florentin, J., Brouste, Y., Gueye, P., Megarbane, B., & Mehdaoui, H. (2020). Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes. Toxics, 8(2), . https://doi.org/10.3390/toxics8020028
Resiere, Dabor, et al. "Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes." Toxics vol. 8,2 (2020). doi: https://doi.org/10.3390/toxics8020028
Resiere D, Kallel H, Oxybel O, Chabartier C, Florentin J, Brouste Y, Gueye P, Megarbane B, Mehdaoui H. Clinical and Epidemiological Characteristics of Severe Acute Adult Poisoning Cases in Martinique: Implicated Toxic Exposures and Their Outcomes. Toxics. 2020 Apr 09;8(2). doi: 10.3390/toxics8020028. PMID: 32283693; PMCID: PMC7356022.
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The Correlation Between Serum Adipokines and Liver Cell Damage in Non-Alcoholic Fatty Liver Disease.

Hepatitis monthly

Jamali R, Hatami N, Kosari F.
PMID: 27313636
Hepat Mon. 2016 Apr 20;16(5):e37412. doi: 10.5812/hepatmon.37412. eCollection 2016 May.

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronic hepatitis, which can lead to cirrhosis and hepatocellular carcinoma.OBJECTIVES: The aim of the study was to evaluate the correlation between serum adipocytokines and the histologic findings of...

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Jamali R, Hatami N, Kosari F. The Correlation Between Serum Adipokines and Liver Cell Damage in Non-Alcoholic Fatty Liver Disease. Hepat Mon. 2016;16(5):e37412doi: 10.5812/hepatmon.37412.
Jamali, R., Hatami, N., & Kosari, F. (2016). The Correlation Between Serum Adipokines and Liver Cell Damage in Non-Alcoholic Fatty Liver Disease. Hepatitis monthly, 16(5), e37412. https://doi.org/10.5812/hepatmon.37412
Jamali, Raika, et al. "The Correlation Between Serum Adipokines and Liver Cell Damage in Non-Alcoholic Fatty Liver Disease." Hepatitis monthly vol. 16,5 (2016): e37412. doi: https://doi.org/10.5812/hepatmon.37412
Jamali R, Hatami N, Kosari F. The Correlation Between Serum Adipokines and Liver Cell Damage in Non-Alcoholic Fatty Liver Disease. Hepat Mon. 2016 Apr 20;16(5):e37412. doi: 10.5812/hepatmon.37412. eCollection 2016 May. PMID: 27313636; PMCID: PMC4906707.
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α-Glutathione S-Transferase: A New Biomarker for Liver Injury?.

The journal of applied laboratory medicine

Maina I, Rule JA, Wians FH, Poirier M, Grant L, Lee WM.
PMID: 33626782
J Appl Lab Med. 2016 Sep 01;1(2):119-128. doi: 10.1373/jalm.2016.020412.

BACKGROUND: Serum alanine and aspartate aminotransferases (ALT/AST) have been the gold standard for detection and quantification of liver injury for over 6 decades, but have relatively long half-lives (T½) (literature estimates approximately 17 and 47 h, respectively) and thus...

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Maina I, Rule JA, Wians FH, et al. α-Glutathione S-Transferase: A New Biomarker for Liver Injury?. J Appl Lab Med. 2016;1(2):119-128doi: 10.1373/jalm.2016.020412.
Maina, I., Rule, J. A., Wians, F. H., Poirier, M., Grant, L., & Lee, W. M. (2016). α-Glutathione S-Transferase: A New Biomarker for Liver Injury?. The journal of applied laboratory medicine, 1(2), 119-128. https://doi.org/10.1373/jalm.2016.020412
Maina, Ian, et al. "α-Glutathione S-Transferase: A New Biomarker for Liver Injury?." The journal of applied laboratory medicine vol. 1,2 (2016): 119-128. doi: https://doi.org/10.1373/jalm.2016.020412
Maina I, Rule JA, Wians FH, Poirier M, Grant L, Lee WM. α-Glutathione S-Transferase: A New Biomarker for Liver Injury?. J Appl Lab Med. 2016 Sep 01;1(2):119-128. doi: 10.1373/jalm.2016.020412. PMID: 33626782.
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Efficacy and Safety of Metreleptin in Patients with Partial Lipodystrophy: Lessons from an Expanded Access Program.

Journal of diabetes & metabolism

Ajluni N, Dar M, Xu J, Neidert AH, Oral EA.
PMID: 27642538
J Diabetes Metab. 2016 Mar;7(3). doi: 10.4172/2155-6156.1000659. Epub 2016 Mar 23.

OBJECTIVE: Patients with lipodystrophy have severe metabolic abnormalities (insulin resistance, diabetes, and hypertriglyceridemia) that may increase morbidity and mortality. Metreleptin is approved by the United States Food and Drug Administration for treatment of generalized forms of lipodystrophy. We aimed...

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Ajluni N, Dar M, Xu J, et al. Efficacy and Safety of Metreleptin in Patients with Partial Lipodystrophy: Lessons from an Expanded Access Program. J Diabetes Metab. 2016;7(3)doi: 10.4172/2155-6156.1000659.
Ajluni, N., Dar, M., Xu, J., Neidert, A. H., & Oral, E. A. (2016). Efficacy and Safety of Metreleptin in Patients with Partial Lipodystrophy: Lessons from an Expanded Access Program. Journal of diabetes & metabolism, 7(3), . https://doi.org/10.4172/2155-6156.1000659
Ajluni, Nevin, et al. "Efficacy and Safety of Metreleptin in Patients with Partial Lipodystrophy: Lessons from an Expanded Access Program." Journal of diabetes & metabolism vol. 7,3 (2016). doi: https://doi.org/10.4172/2155-6156.1000659
Ajluni N, Dar M, Xu J, Neidert AH, Oral EA. Efficacy and Safety of Metreleptin in Patients with Partial Lipodystrophy: Lessons from an Expanded Access Program. J Diabetes Metab. 2016 Mar;7(3). doi: 10.4172/2155-6156.1000659. Epub 2016 Mar 23. PMID: 27642538; PMCID: PMC5026130.
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Effects of sodium-glucose co-transporter 2 inhibitors on liver parameters and steatosis: A meta-analysis of randomized clinical trials.

Diabetes/metabolism research and reviews

Coelho FDS, Borges-Canha M, von Hafe M, Neves JS, Vale C, Leite AR, Carvalho D, Leite-Moreira A.
PMID: 33010191
Diabetes Metab Res Rev. 2021 Sep;37(6):e3413. doi: 10.1002/dmrr.3413. Epub 2020 Oct 12.

AIMS: Non-alcoholic fatty liver disease (NAFLD) is the most common form of chronic liver disease in Western countries and a common comorbidity with type 2 diabetes (T2D). It lacks effective pharmacotherapy. We aimed to summarize the evidence on the...

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Coelho FDS, Borges-Canha M, von Hafe M, et al. Effects of sodium-glucose co-transporter 2 inhibitors on liver parameters and steatosis: A meta-analysis of randomized clinical trials. Diabetes Metab Res Rev. 2020;37(6):e3413doi: 10.1002/dmrr.3413.
Coelho, F. D. S., Borges-Canha, M., von Hafe, M., Neves, J. S., Vale, C., Leite, A. R., Carvalho, D., & Leite-Moreira, A. (2021). Effects of sodium-glucose co-transporter 2 inhibitors on liver parameters and steatosis: A meta-analysis of randomized clinical trials. Diabetes/metabolism research and reviews, 37(6), e3413. https://doi.org/10.1002/dmrr.3413
Coelho, Francisca Dos Santos, et al. "Effects of sodium-glucose co-transporter 2 inhibitors on liver parameters and steatosis: A meta-analysis of randomized clinical trials." Diabetes/metabolism research and reviews vol. 37,6 (2021): e3413. doi: https://doi.org/10.1002/dmrr.3413
Coelho FDS, Borges-Canha M, von Hafe M, Neves JS, Vale C, Leite AR, Carvalho D, Leite-Moreira A. Effects of sodium-glucose co-transporter 2 inhibitors on liver parameters and steatosis: A meta-analysis of randomized clinical trials. Diabetes Metab Res Rev. 2021 Sep;37(6):e3413. doi: 10.1002/dmrr.3413. Epub 2020 Oct 12. PMID: 33010191.
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Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model.

Journal of ethnopharmacology

Xu Z, Lin S, Tong Z, Chen S, Cao Y, Li Q, Jiang Y, Cai W, Tong Y, Zahra BS, Wang P.
PMID: 34848360
J Ethnopharmacol. 2021 Nov 27;285:114873. doi: 10.1016/j.jep.2021.114873. Epub 2021 Nov 27.

ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicine considers that the etiology and pathogenesis of non-alcoholic fatty liver disease (NAFLD) are related to liver depression and qi stagnation. Saffron and its active ingredient, crocetin (CCT), are used for the treatment of metabolic...

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Xu Z, Lin S, Tong Z, et al. Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model. J Ethnopharmacol. 2021;285:114873doi: 10.1016/j.jep.2021.114873.
Xu, Z., Lin, S., Tong, Z., Chen, S., Cao, Y., Li, Q., Jiang, Y., Cai, W., Tong, Y., Zahra, B. S., & Wang, P. (2021). Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model. Journal of ethnopharmacology, 285114873. https://doi.org/10.1016/j.jep.2021.114873
Xu, Zijin, et al. "Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model." Journal of ethnopharmacology vol. 285 (2021): 114873. doi: https://doi.org/10.1016/j.jep.2021.114873
Xu Z, Lin S, Tong Z, Chen S, Cao Y, Li Q, Jiang Y, Cai W, Tong Y, Zahra BS, Wang P. Crocetin ameliorates non-alcoholic fatty liver disease by modulating mitochondrial dysfunction in L02 cells and zebrafish model. J Ethnopharmacol. 2021 Nov 27;285:114873. doi: 10.1016/j.jep.2021.114873. Epub 2021 Nov 27. PMID: 34848360.
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