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Synthesis, SAR Study and Evaluation of Mannich and Schiff Bases of Pyrazol-5(4H)-one Moiety Containing 3-(Hydrazinyl)-2-phenylquinazolin-4(3H)-one.

Indian journal of pharmaceutical sciences

Sivakumar KK, Rajasekharan A, Rao R, Narasimhan B.
PMID: 24302802
Indian J Pharm Sci. 2013 Jul;75(4):463-75. doi: 10.4103/0250-474X.119832.

In the present investigation, a series of 12 Mannich bases (QP1-12) and 5 Schiff bases (QSP1-5) of pyrazol-5(4H)-one moiety containing 3-(hydrazinyl)-2-phenylquinazolin-4(3H)-one has been synthesized and characterized by physicochemical as well as spectral means. The synthesized Mannich and Schiff bases...

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Sivakumar KK, Rajasekharan A, Rao R, et al. Synthesis, SAR Study and Evaluation of Mannich and Schiff Bases of Pyrazol-5(4H)-one Moiety Containing 3-(Hydrazinyl)-2-phenylquinazolin-4(3H)-one. Indian J Pharm Sci. 2013;75(4):463-75doi: 10.4103/0250-474X.119832.
Sivakumar, K. K., Rajasekharan, A., Rao, R., & Narasimhan, B. (2013). Synthesis, SAR Study and Evaluation of Mannich and Schiff Bases of Pyrazol-5(4H)-one Moiety Containing 3-(Hydrazinyl)-2-phenylquinazolin-4(3H)-one. Indian journal of pharmaceutical sciences, 75(4), 463-75. https://doi.org/10.4103/0250-474X.119832
Sivakumar, K K, et al. "Synthesis, SAR Study and Evaluation of Mannich and Schiff Bases of Pyrazol-5(4H)-one Moiety Containing 3-(Hydrazinyl)-2-phenylquinazolin-4(3H)-one." Indian journal of pharmaceutical sciences vol. 75,4 (2013): 463-75. doi: https://doi.org/10.4103/0250-474X.119832
Sivakumar KK, Rajasekharan A, Rao R, Narasimhan B. Synthesis, SAR Study and Evaluation of Mannich and Schiff Bases of Pyrazol-5(4H)-one Moiety Containing 3-(Hydrazinyl)-2-phenylquinazolin-4(3H)-one. Indian J Pharm Sci. 2013 Jul;75(4):463-75. doi: 10.4103/0250-474X.119832. PMID: 24302802; PMCID: PMC3831729.
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Data-mining of potential antitubercular activities from molecular ingredients of traditional Chinese medicines.

PeerJ

Jamal S, Scaria V.
PMID: 25081126
PeerJ. 2014 Jul 17;2:e476. doi: 10.7717/peerj.476. eCollection 2014.

Background. Traditional Chinese medicine encompasses a well established alternate system of medicine based on a broad range of herbal formulations and is practiced extensively in the region for the treatment of a wide variety of diseases. In recent years,...

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Jamal S, Scaria V. Data-mining of potential antitubercular activities from molecular ingredients of traditional Chinese medicines. PeerJ. 2014;2:e476doi: 10.7717/peerj.476.
Jamal, S., Scaria, V. (2014). Data-mining of potential antitubercular activities from molecular ingredients of traditional Chinese medicines. PeerJ, 2e476. https://doi.org/10.7717/peerj.476
Jamal, Salma, et al. "Data-mining of potential antitubercular activities from molecular ingredients of traditional Chinese medicines." PeerJ vol. 2 (2014): e476. doi: https://doi.org/10.7717/peerj.476
Jamal S, Scaria V. Data-mining of potential antitubercular activities from molecular ingredients of traditional Chinese medicines. PeerJ. 2014 Jul 17;2:e476. doi: 10.7717/peerj.476. eCollection 2014. PMID: 25081126; PMCID: PMC4106188.
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Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents.

ACS medicinal chemistry letters

Tang J, Wang B, Wu T, Wan J, Tu Z, Njire M, Wan B, Franzblauc SG, Zhang T, Lu X, Ding K.
PMID: 26191372
ACS Med Chem Lett. 2015 Jun 11;6(7):814-8. doi: 10.1021/acsmedchemlett.5b00176. eCollection 2015 Jul 09.

A series of pyrazolo[1,5-a]pyridine-3-carboxamide derivatives were designed and synthesized as new anti-Mycobacterium tuberculosis (Mtb) agents. The compounds exhibit promising in vitro potency with nanomolar MIC values against the drug susceptive H37Rv strain and a panel of clinically isolated multidrug-resistant...

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Tang J, Wang B, Wu T, et al. Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents. ACS Med Chem Lett. 2015;6(7):814-8doi: 10.1021/acsmedchemlett.5b00176.
Tang, J., Wang, B., Wu, T., Wan, J., Tu, Z., Njire, M., Wan, B., Franzblauc, S. G., Zhang, T., Lu, X., & Ding, K. (2015). Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents. ACS medicinal chemistry letters, 6(7), 814-8. https://doi.org/10.1021/acsmedchemlett.5b00176
Tang, Jian, et al. "Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents." ACS medicinal chemistry letters vol. 6,7 (2015): 814-8. doi: https://doi.org/10.1021/acsmedchemlett.5b00176
Tang J, Wang B, Wu T, Wan J, Tu Z, Njire M, Wan B, Franzblauc SG, Zhang T, Lu X, Ding K. Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents. ACS Med Chem Lett. 2015 Jun 11;6(7):814-8. doi: 10.1021/acsmedchemlett.5b00176. eCollection 2015 Jul 09. PMID: 26191372; PMCID: PMC4499832.
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Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies.

EXCLI journal

Rateb HS, Ahmed HE, Ahmed S, Ihmaid S, Afifi TH.
PMID: 28337109
EXCLI J. 2016 Dec 06;15:781-796. doi: 10.17179/excli2016-654. eCollection 2016.

In continuation of our endeavor towards the design and development of potent and effective antimicrobial agents, three series of phthalimide derivatives (

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Rateb HS, Ahmed HE, Ahmed S, et al. Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies. EXCLI J. 2016;15:781-796doi: 10.17179/excli2016-654.
Rateb, H. S., Ahmed, H. E., Ahmed, S., Ihmaid, S., & Afifi, T. H. (2016). Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies. EXCLI journal, 15781-796. https://doi.org/10.17179/excli2016-654
Rateb, Heba S, et al. "Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies." EXCLI journal vol. 15 (2016): 781-796. doi: https://doi.org/10.17179/excli2016-654
Rateb HS, Ahmed HE, Ahmed S, Ihmaid S, Afifi TH. Discovery of novel phthalimide analogs: Synthesis, antimicrobial and antitubercular screening with molecular docking studies. EXCLI J. 2016 Dec 06;15:781-796. doi: 10.17179/excli2016-654. eCollection 2016. PMID: 28337109; PMCID: PMC5318679.
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pncA Mutations in the Specimens from Extrapulmonary Tuberculosis.

Tuberculosis and respiratory diseases

Lee J, Yun YJ, Kqueen CY, Lee JH, Kim HY, Kim YR, Kook YH, Lee KH.
PMID: 23101013
Tuberc Respir Dis (Seoul). 2012 Jun;72(6):475-80. doi: 10.4046/trd.2012.72.6.475. Epub 2012 Jun 29.

BACKGROUND: Pyrazinamide (PZA) is an effective antitubercular drug that becomes toxic to Mycobacterium tuberculosis when converted to pyrazinoic acid by pyrazinamidase (PZase), encoded by mycobacterial pncA. A strong association was noted between the loss of PZase activity and PZA...

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Lee J, Yun YJ, Kqueen CY, et al. pncA Mutations in the Specimens from Extrapulmonary Tuberculosis. Tuberc Respir Dis (Seoul). 2012;72(6):475-80doi: 10.4046/trd.2012.72.6.475.
Lee, J., Yun, Y. J., Kqueen, C. Y., Lee, J. H., Kim, H. Y., Kim, Y. R., Kook, Y. H., & Lee, K. H. (2012). pncA Mutations in the Specimens from Extrapulmonary Tuberculosis. Tuberculosis and respiratory diseases, 72(6), 475-80. https://doi.org/10.4046/trd.2012.72.6.475
Lee, Jaechun, et al. "pncA Mutations in the Specimens from Extrapulmonary Tuberculosis." Tuberculosis and respiratory diseases vol. 72,6 (2012): 475-80. doi: https://doi.org/10.4046/trd.2012.72.6.475
Lee J, Yun YJ, Kqueen CY, Lee JH, Kim HY, Kim YR, Kook YH, Lee KH. pncA Mutations in the Specimens from Extrapulmonary Tuberculosis. Tuberc Respir Dis (Seoul). 2012 Jun;72(6):475-80. doi: 10.4046/trd.2012.72.6.475. Epub 2012 Jun 29. PMID: 23101013; PMCID: PMC3475457.
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Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs.

Indian journal of pharmaceutical sciences

Viswanathan V, Phadatare AG, Mukne A.
PMID: 25035540
Indian J Pharm Sci. 2014 May;76(3):256-61.

Tuberculosis is one of the major public health problems faced globally. Resistance of Mycobacterium tuberculosis to antitubercular agents has called for an urgent need to investigate newer drugs to combat tuberculosis. Garlic (Allium sativum) is an edible plant which...

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Viswanathan V, Phadatare AG, Mukne A. Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs. Indian J Pharm Sci. 2014;76(3):256-61
Viswanathan, V., Phadatare, A. G., & Mukne, A. (2014). Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs. Indian journal of pharmaceutical sciences, 76(3), 256-61.
Viswanathan, V, et al. "Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs." Indian journal of pharmaceutical sciences vol. 76,3 (2014): 256-61.
Viswanathan V, Phadatare AG, Mukne A. Antimycobacterial and Antibacterial Activity of Allium sativum Bulbs. Indian J Pharm Sci. 2014 May;76(3):256-61. PMID: 25035540; PMCID: PMC4090836.
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Tuberculosis affecting multiple vertebral bodies.

Asian spine journal

Baba H, Tagami A, Adachi S, Hiura T, Osaki M.
PMID: 24066219
Asian Spine J. 2013 Sep;7(3):222-6. doi: 10.4184/asj.2013.7.3.222. Epub 2013 Sep 04.

Spinal tuberculosis usually occurs in a single vertebral body or two to three adjacent vertebrae; it rarely occurs in multiple vertebral bodies. Surgery is indicated in cases that do not improve with conservative therapy, or when paralysis is evident....

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Baba H, Tagami A, Adachi S, et al. Tuberculosis affecting multiple vertebral bodies. Asian Spine J. 2013;7(3):222-6doi: 10.4184/asj.2013.7.3.222.
Baba, H., Tagami, A., Adachi, S., Hiura, T., & Osaki, M. (2013). Tuberculosis affecting multiple vertebral bodies. Asian spine journal, 7(3), 222-6. https://doi.org/10.4184/asj.2013.7.3.222
Baba, Hideo, et al. "Tuberculosis affecting multiple vertebral bodies." Asian spine journal vol. 7,3 (2013): 222-6. doi: https://doi.org/10.4184/asj.2013.7.3.222
Baba H, Tagami A, Adachi S, Hiura T, Osaki M. Tuberculosis affecting multiple vertebral bodies. Asian Spine J. 2013 Sep;7(3):222-6. doi: 10.4184/asj.2013.7.3.222. Epub 2013 Sep 04. PMID: 24066219; PMCID: PMC3779775.
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Extensively Drug-resistant Tuberculosis of the Lumbar Spine in a Six-year-old Child: A Case Report.

Journal of orthopaedic case reports

Shah SS, Goregaonkar AA, Goregaonkar AB.
PMID: 28819600
J Orthop Case Rep. 2017 Mar-Apr;7(2):40-43. doi: 10.13107/jocr.2250-0685.742.

INTRODUCTION: The emergence of extensively drug-resistant tuberculosis (XDR-TB) is a challenging paradigm shift faced by the TB control programs worldwide today. The treatment is further compounded with unique management difficulties faced in pediatric patients. Treatment of XDR-TB requires prolonged...

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Shah SS, Goregaonkar AA, Goregaonkar AB. Extensively Drug-resistant Tuberculosis of the Lumbar Spine in a Six-year-old Child: A Case Report. J Orthop Case Rep. 2017;7(2):40-43doi: 10.13107/jocr.2250-0685.742.
Shah, S. S., Goregaonkar, A. A., & Goregaonkar, A. B. (2017). Extensively Drug-resistant Tuberculosis of the Lumbar Spine in a Six-year-old Child: A Case Report. Journal of orthopaedic case reports, 7(2), 40-43. https://doi.org/10.13107/jocr.2250-0685.742
Shah, Siddharth Sanjay, et al. "Extensively Drug-resistant Tuberculosis of the Lumbar Spine in a Six-year-old Child: A Case Report." Journal of orthopaedic case reports vol. 7,2 (2017): 40-43. doi: https://doi.org/10.13107/jocr.2250-0685.742
Shah SS, Goregaonkar AA, Goregaonkar AB. Extensively Drug-resistant Tuberculosis of the Lumbar Spine in a Six-year-old Child: A Case Report. J Orthop Case Rep. 2017 Mar-Apr;7(2):40-43. doi: 10.13107/jocr.2250-0685.742. PMID: 28819600; PMCID: PMC5553834.
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DRUG RESISTANT TUBERCULOSIS - THE EMERGING SCENARIO.

Medical journal, Armed Forces India

Jena J, Nema SK, Panda BN.
PMID: 28769352
Med J Armed Forces India. 1996 Apr;52(2):87-90. doi: 10.1016/S0377-1237(17)30850-X. Epub 2017 Jun 26.

During the period April 1992 to September 1994 a total of 2288 patients of pulmonary tuberculosis were treated at our centre.

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Jena J, Nema SK, Panda BN. DRUG RESISTANT TUBERCULOSIS - THE EMERGING SCENARIO. Med J Armed Forces India. 2017;52(2):87-90doi: 10.1016/S0377-1237(17)30850-X.
Jena, J., Nema, S. K., & Panda, B. N. (1996). DRUG RESISTANT TUBERCULOSIS - THE EMERGING SCENARIO. Medical journal, Armed Forces India, 52(2), 87-90. https://doi.org/10.1016/S0377-1237(17)30850-X
Jena, J, et al. "DRUG RESISTANT TUBERCULOSIS - THE EMERGING SCENARIO." Medical journal, Armed Forces India vol. 52,2 (1996): 87-90. doi: https://doi.org/10.1016/S0377-1237(17)30850-X
Jena J, Nema SK, Panda BN. DRUG RESISTANT TUBERCULOSIS - THE EMERGING SCENARIO. Med J Armed Forces India. 1996 Apr;52(2):87-90. doi: 10.1016/S0377-1237(17)30850-X. Epub 2017 Jun 26. PMID: 28769352; PMCID: PMC5530262.
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Development of pseudomembranous colitis four months after initiation of rifampicin.

Case reports in gastroenterology

Choi JM, Kim HH, Park SJ, Park MI, Moon W.
PMID: 21326858
Case Rep Gastroenterol. 2011 Jan 14;5(1):45-51. doi: 10.1159/000323753.

Pseudomembranous colitis (PMC) may develop with long-term antibiotic administration, but is rarely reported to be caused by antitubercular agents. We present a case of PMC that occurred 120 days after starting rifampicin. A 74-year-old man was diagnosed with pulmonary...

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Choi JM, Kim HH, Park SJ, et al. Development of pseudomembranous colitis four months after initiation of rifampicin. Case Rep Gastroenterol. 2011;5(1):45-51doi: 10.1159/000323753.
Choi, J. M., Kim, H. H., Park, S. J., Park, M. I., & Moon, W. (2011). Development of pseudomembranous colitis four months after initiation of rifampicin. Case reports in gastroenterology, 5(1), 45-51. https://doi.org/10.1159/000323753
Choi, Jeong Moon, et al. "Development of pseudomembranous colitis four months after initiation of rifampicin." Case reports in gastroenterology vol. 5,1 (2011): 45-51. doi: https://doi.org/10.1159/000323753
Choi JM, Kim HH, Park SJ, Park MI, Moon W. Development of pseudomembranous colitis four months after initiation of rifampicin. Case Rep Gastroenterol. 2011 Jan 14;5(1):45-51. doi: 10.1159/000323753. PMID: 21326858; PMCID: PMC3037994.
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A case of pulmonary tuberculosis diagnosed in a patient with manifestations of haemophagocytic lymphohistiocytosis.

Oxford medical case reports

Ohata S, Hara K, Arai T, Takayoshi T, Nishiyama K, Yasutomo Y, Yokono K, Sugimoto T.
PMID: 30949351
Oxf Med Case Reports. 2019 Mar 29;2019(3):omz013. doi: 10.1093/omcr/omz013. eCollection 2019 Mar.

An 80-year-old woman was admitted with continuous fever, hepatic dysfunction and cytopaenia. The presence of hepatosplenomegaly, hyperferritinaemia, hypofibrinogenaemia and phagocytosis by macrophages in the bone marrow was consistent with a diagnosis of haemophagocytic lymphohistiocytosis (HLH). We suspected that HLH...

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Ohata S, Hara K, Arai T, et al. A case of pulmonary tuberculosis diagnosed in a patient with manifestations of haemophagocytic lymphohistiocytosis. Oxf Med Case Reports. 2019;2019(3):omz013doi: 10.1093/omcr/omz013.
Ohata, S., Hara, K., Arai, T., Takayoshi, T., Nishiyama, K., Yasutomo, Y., Yokono, K., & Sugimoto, T. (2019). A case of pulmonary tuberculosis diagnosed in a patient with manifestations of haemophagocytic lymphohistiocytosis. Oxford medical case reports, 2019(3), omz013. https://doi.org/10.1093/omcr/omz013
Ohata, Shinya, et al. "A case of pulmonary tuberculosis diagnosed in a patient with manifestations of haemophagocytic lymphohistiocytosis." Oxford medical case reports vol. 2019,3 (2019): omz013. doi: https://doi.org/10.1093/omcr/omz013
Ohata S, Hara K, Arai T, Takayoshi T, Nishiyama K, Yasutomo Y, Yokono K, Sugimoto T. A case of pulmonary tuberculosis diagnosed in a patient with manifestations of haemophagocytic lymphohistiocytosis. Oxf Med Case Reports. 2019 Mar 29;2019(3):omz013. doi: 10.1093/omcr/omz013. eCollection 2019 Mar. PMID: 30949351; PMCID: PMC6440261.
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Dataset of 2-(2-(4-aryloxybenzylidene) hydrazinyl) benzothiazole derivatives for GQSAR of antitubercular agents.

Data in brief

Tapkir AS, Chitlange SS, Bhole RP.
PMID: 28831410
Data Brief. 2017 Aug 09;14:469-473. doi: 10.1016/j.dib.2017.08.006. eCollection 2017 Oct.

Fragment based Quantitative structure activity relationship (QSAR) analysis on reported 25 2-(2-(4-aryloxybenzylidene) hydrazinyl) benzothiazole dataset as antitubercular agents were carried out. Molecules in the current dataset were fragmented into six fragments (R1, R2, R3, R4, R5, R6).Group based QSAR...

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Tapkir AS, Chitlange SS, Bhole RP. Dataset of 2-(2-(4-aryloxybenzylidene) hydrazinyl) benzothiazole derivatives for GQSAR of antitubercular agents. Data Brief. 2017;14:469-473doi: 10.1016/j.dib.2017.08.006.
Tapkir, A. S., Chitlange, S. S., & Bhole, R. P. (2017). Dataset of 2-(2-(4-aryloxybenzylidene) hydrazinyl) benzothiazole derivatives for GQSAR of antitubercular agents. Data in brief, 14469-473. https://doi.org/10.1016/j.dib.2017.08.006
Tapkir, Amit S, et al. "Dataset of 2-(2-(4-aryloxybenzylidene) hydrazinyl) benzothiazole derivatives for GQSAR of antitubercular agents." Data in brief vol. 14 (2017): 469-473. doi: https://doi.org/10.1016/j.dib.2017.08.006
Tapkir AS, Chitlange SS, Bhole RP. Dataset of 2-(2-(4-aryloxybenzylidene) hydrazinyl) benzothiazole derivatives for GQSAR of antitubercular agents. Data Brief. 2017 Aug 09;14:469-473. doi: 10.1016/j.dib.2017.08.006. eCollection 2017 Oct. PMID: 28831410; PMCID: PMC5554989.
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Showing 1 to 12 of 87 entries