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Profile of isavuconazole and its potential in the treatment of severe invasive fungal infections.

Infection and drug resistance

Falci DR, Pasqualotto AC.
PMID: 24187505
Infect Drug Resist. 2013 Oct 22;6:163-74. doi: 10.2147/IDR.S51340.

The triazole class of antifungal drugs comprises first-line agents for the treatment of several invasive fungal diseases. Isavuconazole is a novel broad-spectrum triazole agent. Here we summarize its characteristics and compare it with the currently available antifungal agents. Isavuconazole...

Role of isavuconazole in the treatment of invasive fungal infections.

Therapeutics and clinical risk management

Wilson DT, Dimondi VP, Johnson SW, Jones TM, Drew RH.
PMID: 27536124
Ther Clin Risk Manag. 2016 Aug 03;12:1197-206. doi: 10.2147/TCRM.S90335. eCollection 2016.

Despite recent advances in both diagnosis and prevention, the incidence of invasive fungal infections continues to rise. Available antifungal agents to treat invasive fungal infections include polyenes, triazoles, and echinocandins. Unfortunately, individual agents within each class may be limited...

Transcriptomics Analysis of Candida albicans Treated with Huanglian Jiedu Decoction Using RNA-seq.

Evidence-based complementary and alternative medicine : eCAM

Yang Q, Gao L, Tao M, Chen Z, Yang X, Cao Y.
PMID: 27143984
Evid Based Complement Alternat Med. 2016;2016:3198249. doi: 10.1155/2016/3198249. Epub 2016 Apr 06.

Candida albicans is the major invasive fungal pathogen of humans, causing diseases ranging from superficial mucosal infections to disseminated, systemic infections that are often life-threatening. Resistance of C. albicans to antifungal agents and limited antifungal agents has potentially serious...

Invasive candidiasis in non neutropenic critically ill - need for region-specific management guidelines.

Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine

Ahmed A, Azim A, Baronia AK, Marak RS, Gurjar M.
PMID: 26195859
Indian J Crit Care Med. 2015 Jun;19(6):333-9. doi: 10.4103/0972-5229.158273.

Use of antifungal agents has increased over past few decades. A number of risk factors such as immunosuppression, broad spectrum antibiotics, dialysis, pancreatitis, surgery, etc., have been linked with the increased risk of invasive candidiasis. Though there are various...

Investigation of In Vitro Activity of Five Antifungal Drugs against Dermatophytes Species Isolated from Clinical Samples Using the E-Test Method.

The Eurasian journal of medicine

Aktas AE, Yigit N, Aktas A, Gozubuyuk SG.
PMID: 25610290
Eurasian J Med. 2014 Feb;46(1):26-31. doi: 10.5152/eajm.2014.05.

OBJECTIVE: Dermatomycosis is an infection with fungi related to the skin: glabrous skin, hair and/or nails. Oral treatment of fungal infections in dermatology has become a preferred modality for the management of these very common conditions. Although there are...

Management of invasive candidiasis in nonneutropenic ICU patients.

Therapeutic advances in infectious disease

Weiss E, Timsit JF.
PMID: 25745560
Ther Adv Infect Dis. 2014 Oct;2(5):105-15. doi: 10.1177/2049936114562586.

Invasive candidiasis (IC) is a leading cause of morbidity and mortality among nonneutropenic ICU patients and these life-threatening nosocomial infections require early diagnosis and prompt treatment. However, none of the predictive tools are sufficiently accurate to identify high-risk patients...

Essential Oils and Antifungal Activity.

Pharmaceuticals (Basel, Switzerland)

Nazzaro F, Fratianni F, Coppola R, Feo V.
PMID: 29099084
Pharmaceuticals (Basel). 2017 Nov 02;10(4). doi: 10.3390/ph10040086.

Since ancient times, folk medicine and agro-food science have benefitted from the use of plant derivatives, such as essential oils, to combat different diseases, as well as to preserve food. In Nature, essential oils play a fundamental role in...

Voriconazole plus caspofungin for treatment of invasive fungal infection in children with acute leukemia.

Blood research

Lee KH, Lim YT, Hah JO, Kim YK, Lee CH, Lee JM.
PMID: 29043231
Blood Res. 2017 Sep;52(3):167-173. doi: 10.5045/br.2017.52.3.167. Epub 2017 Sep 25.

BACKGROUND: Invasive fungal infections (IFIs) are a life-threatening problem in immunocompromised patients. Despite timely diagnosis and appropriate antifungal therapy, clinical outcomes of IFIs remain unsatisfactory, necessitating treatment with a combination of antifungal agents. Therefore, childhood leukemic patients treated with...

Identification and Antifungal Susceptibility Testing of .

Journal of global infectious diseases

Kaur R, Dhakad MS, Goyal R, Haque A, Mukhopadhyay G.
PMID: 27942193
J Glob Infect Dis. 2016 Oct-Dec;8(4):139-146. doi: 10.4103/0974-777X.192969.

CONCLUSION: The study confirmed the importance and reliability of conventional and molecular methods, and the acceptable agreements suggest Vitek-2 system an alternative method for speciation and sensitivity testing of Candida species infections.

[Activity of amphotericin B and anidulafungin, alone and combined, against Candida tropicalis biofilms developed on Teflon.

Revista iberoamericana de micologia

Fernández-Rivero ME, Del Pozo JL, Valentín A, Fornes V, Molina de Diego A, Pemán J, Cantón E.
PMID: 28601403
Rev Iberoam Micol. 2017 Jul - Sep;34(3):175-179. doi: 10.1016/j.riam.2017.01.002. Epub 2017 Jun 16.

BACKGROUND: Current therapeutic strategies have a limited efficacy against Candida biofilms that form on the surfaces of biomedical devices. Few studies have evaluated the activity of antifungal agents against Candida tropicalis biofilms.OBJECTIVES: To evaluate the activity of amphotericin B...

Modified ulcer debridement in the treatment of the superficial fungal infection of the cornea.

International journal of ophthalmology

Wang JY, Wang DQ, Qi XL, Cheng J, Xie LX.
PMID: 29487810
Int J Ophthalmol. 2018 Feb 18;11(2):223-229. doi: 10.18240/ijo.2018.02.07. eCollection 2018.

AIM: To evaluate the efficacy of modified corneal ulcer debridement in superficial fungal keratitis unresponsive to medications.METHODS: A total of 209 patients (209 eyes) with fungal keratitis, involving no more than 50% of the stromal depth and not responding...

Sweetgum: An ancient source of beneficial compounds with modern benefits.

Pharmacognosy reviews

Lingbeck JM, O'Bryan CA, Martin EM, Adams JP, Crandall PG.
PMID: 26009686
Pharmacogn Rev. 2015 Jan-Jun;9(17):1-11. doi: 10.4103/0973-7847.156307.

Sweetgum trees are large, deciduous trees found in Asia and North America. Sweetgum trees are important resources for medicinal and other beneficial compounds. Many of the medicinal properties of sweetgum are derived from the resinous sap that exudes when...

Showing 1 to 12 of 1046 entries