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Showing 1 to 12 of 1720 entries
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The role of androgens in metabolism, obesity, and diabetes in males and females

STEM and males

Allard C, Mauvais‐Jarvis F, Xu W.
GSID: d70eNxgIjX0J
G Navarro, C Allard, W Xu, F Mauvais‐Jarvis - Obesity, 2015 - Wiley Online Library

… that in males, testosterone has … in males is indirectly mediated via AR signaling in skeletal muscle. First, in vitro, testosterone stimulates the commitment of pluripotent mesenchymal stem …

Androgens and adipose tissue in males: a complex and reciprocal interplay

STEM and males

[No authors listed]
GSID: 3jLFl0xQNIEJ
C Mammi, M Calanchini, A Antelmi, F Cinti… - International journal of …, 2012 - hindawi.com

Clinical evidence shows that in males obesity is frequently associated with hypogonadism and vice versa; also, low testosterone levels have been considered a “hallmark” of metabolic …

Quality of Life and Sexual Health in the Aging of PCa Survivors.

International journal of endocrinology

Gacci M, Baldi E, Tamburrino L, Detti B, Livi L, De Nunzio C, Tubaro A, Gravas S, Carini M, Serni S.
PMID: 24744780
Int J Endocrinol. 2014;2014:470592. doi: 10.1155/2014/470592. Epub 2014 Mar 17.

Prostate cancer (PCa) is the most common malignancy in elderly men. The progressive ageing of the world male population will further increase the need for tailored assessment and treatment of PCa patients. The determinant role of androgens and sexual...

Sex Differences in Asthma: A Key Role of Androgen-Signaling in Group 2 Innate Lymphoid Cells.

Frontiers in immunology

Laffont S, Blanquart E, Guéry JC.
PMID: 28912783
Front Immunol. 2017 Aug 31;8:1069. doi: 10.3389/fimmu.2017.01069. eCollection 2017.

Infectious diseases, autoimmune diseases, and also allergy differentially affect women and men. In general, women develop strongest immune responses and thus the proportion of infected individuals and the severity of many viral, bacterial, or parasitic infections are increased in...

Spatial Localization and Quantitation of Androgens in Mouse Testis by Mass Spectrometry Imaging.

Analytical chemistry

Cobice DF, Livingstone DE, Mackay CL, Goodwin RJ, Smith LB, Walker BR, Andrew R.
PMID: 27676129
Anal Chem. 2016 Nov 01;88(21):10362-10367. doi: 10.1021/acs.analchem.6b02242. Epub 2016 Oct 14.

Androgens are essential for male development and reproductive function. They are transported to their site of action as blood-borne endocrine hormones but can also be produced within tissues to act in intracrine and paracrine fashions. Because of this, circulating...

The Androgen Receptor and VEGF: Mechanisms of Androgen-Regulated Angiogenesis in Prostate Cancer.

Cancers

Eisermann K, Fraizer G.
PMID: 28394264
Cancers (Basel). 2017 Apr 10;9(4). doi: 10.3390/cancers9040032.

Prostate cancer progression is controlled by the androgen receptor and new blood vessel formation, or angiogenesis, which promotes metastatic prostate cancer growth. Angiogenesis is induced by elevated expression of vascular endothelial growth factor (VEGF). VEGF is regulated by many...

Cholestatic Jaundice With the Use of Methylstenbolone and Dymethazine, Designer Steroids Found in Super DMZ Rx 2.0 "Nutritional Supplement": A Case Report.

Journal of investigative medicine high impact case reports

Agbenyefia P, Arnold CA, Kirkpatrick R.
PMID: 26425606
J Investig Med High Impact Case Rep. 2014 Apr 22;2(2):2324709614532800. doi: 10.1177/2324709614532800. eCollection 2014.

"Nutritional supplements" that promise an increase in muscle mass and strength are becoming a go to item as enhancing one's physical appearance becomes a more important part of our society. This is alarming because many of these nutritional supplements...

Drug resistance in castration resistant prostate cancer: resistance mechanisms and emerging treatment strategies.

American journal of clinical and experimental urology

Armstrong CM, Gao AC.
PMID: 26309896
Am J Clin Exp Urol. 2015 Aug 08;3(2):64-76. eCollection 2015.

Several mechanisms facilitate the progression of hormone-sensitive prostate cancer to castration-resistant prostate cancer (CRPC). At present, the approved chemotherapies for CRPC include systemic drugs (docetaxel and cabazitaxel) and agents that target androgen signaling, including enzalutamide and abiraterone. While up...

Testosterone increases circulating dehydroepiandrosterone sulfate levels in the male rhesus macaque.

Frontiers in endocrinology

Sorwell KG, Kohama SG, Urbanski HF.
PMID: 25009533
Front Endocrinol (Lausanne). 2014 Jun 25;5:101. doi: 10.3389/fendo.2014.00101. eCollection 2014.

The adrenal steroid dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are two of the most abundant hormones in the human circulation. Furthermore, they are released in a circadian pattern and show a marked age-associated decline. Adult levels of DHEA and...

Effects of Androgen and Estrogen Receptor Signaling Pathways on Bladder Cancer Initiation and Progression.

Bladder cancer (Amsterdam, Netherlands)

Godoy G, Gakis G, Smith CL, Fahmy O.
PMID: 27376135
Bladder Cancer. 2016 Apr 27;2(2):127-137. doi: 10.3233/BLC-160052.

Epidemiologic studies have long demonstrated clear differences in incidence and progression of bladder cancer between genders suggesting that the mechanisms of development and progression in these tumors have a strong association with steroid hormonal pathways. Such observations led to...

Harem-holding males do not rise to the challenge: androgens respond to social but not to seasonal challenges in wild geladas.

Royal Society open science

Pappano DJ, Beehner JC.
PMID: 26064526
R Soc Open Sci. 2014 Sep 24;1(1):140081. doi: 10.1098/rsos.140081. eCollection 2014 Sep.

The challenge hypothesis has been enormously successful in predicting interspecific androgen profiles for vertebrate males. Nevertheless, in the absence of another theoretical framework, many researchers 'retrofit' the challenge hypothesis, so that its predictions also apply to intraspecific androgen comparisons....

Spatial sexual dimorphism of X and Y homolog gene expression in the human central nervous system during early male development.

Biology of sex differences

Johansson MM, Lundin E, Qian X, Mirzazadeh M, Halvardson J, Darj E, Feuk L, Nilsson M, Jazin E.
PMID: 26759715
Biol Sex Differ. 2016 Jan 12;7:5. doi: 10.1186/s13293-015-0056-4. eCollection 2016.

BACKGROUND: Renewed attention has been directed to the functions of the Y chromosome in the central nervous system during early human male development, due to the recent proposed involvement in neurodevelopmental diseases. PCDH11Y and NLGN4Y are of special interest...

Showing 1 to 12 of 1720 entries