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Showing 1 to 12 of 26 entries
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Effects of Androgen and Estrogen Receptor Signaling Pathways on Bladder Cancer Initiation and Progression.

Bladder cancer (Amsterdam, Netherlands)

Godoy G, Gakis G, Smith CL, Fahmy O.
PMID: 27376135
Bladder Cancer. 2016 Apr 27;2(2):127-137. doi: 10.3233/BLC-160052.

Epidemiologic studies have long demonstrated clear differences in incidence and progression of bladder cancer between genders suggesting that the mechanisms of development and progression in these tumors have a strong association with steroid hormonal pathways. Such observations led to...

Androgen deprivation therapy for prostate cancer-review of indications in 2010.

Current oncology (Toronto, Ont.)

Quon H, Loblaw DA.
PMID: 20882131
Curr Oncol. 2010 Sep;17:S38-44. doi: 10.3747/co.v17i0.698.

The discovery of androgen deprivation therapy (ADT) has been one of the most important advances in the treatment of prostate cancer. Here, the indications for the use of ADT are reviewed, together with the data supporting each indication. The...

Identifying 5 Common Psychiatric Disorders Associated Chemicals Through Integrative Analysis of Genome-Wide Association Study and Chemical-Gene Interaction Datasets.

Schizophrenia bulletin

Cheng S, Wen Y, Ma M, Zhang L, Liu L, Qi X, Cheng B, Liang C, Li P, Kafle OP, Zhang F.
PMID: 32291453
Schizophr Bull. 2020 Apr 15; doi: 10.1093/schbul/sbaa053. Epub 2020 Apr 15.

Psychiatric disorders are a group of complex psychological syndromes whose etiology remains unknown. Previous study suggested that various chemicals contributed to the development of psychiatric diseases through affecting gene expression. This study aims to systematically explore the potential relationships...

Multidisciplinary Consensus on the Prevention and Treatment of Osteoporosis and Fragility Fractures in Patients with Prostate Cancer Receiving Androgen-Deprivation Therapy.

The world journal of men's health

Casado E, Borque-Fernando A, Caamaño M, Graña J, Muñoz-Rodríguez J, Morote J.
PMID: 34983087
World J Mens Health. 2022 Jan;40(1):74-86. doi: 10.5534/wjmh.210061.

Patients with prostate cancer (PCa) on androgen-deprivation therapy (ADT) are at high risk of osteoporosis and fragility fractures. We aimed to provide some practical insights into the delivery of optimal bone health care for PCa patients, particularly those on...

The role of cannabinoids in prostate cancer: Basic science perspective and potential clinical applications.

Indian journal of urology : IJU : journal of the Urological Society of India

Ramos JA, Bianco FJ.
PMID: 22557710
Indian J Urol. 2012 Jan;28(1):9-14. doi: 10.4103/0970-1591.94942.

Prostate cancer is a global public health problem, and it is the most common cancer in American men and the second cause for cancer-related death. Experimental evidence shows that prostate tissue possesses cannabinoid receptors and their stimulation results in...

Deep Prostate-specific Antigen Response following Addition of Apalutamide to Ongoing Androgen Deprivation Therapy and Long-term Clinical Benefit in SPARTAN.

European urology

Saad F, Small EJ, Feng FY, Graff JN, Olmos D, Hadaschik BA, Oudard S, Londhe A, Bhaumik A, Lopez-Gitlitz A, Thomas S, Mundle SD, Chowdhury S, Smith MR.
PMID: 34916086
Eur Urol. 2021 Dec 13; doi: 10.1016/j.eururo.2021.11.020. Epub 2021 Dec 13.

BACKGROUND: Apalutamide plus androgen deprivation therapy (ADT) significantly improved metastasis-free survival (MFS), overall survival (OS), and time to prostate-specific antigen (PSA) progression in the placebo-controlled SPARTAN study of high-risk nonmetastatic castration-resistant prostate cancer (nmCRPC).OBJECTIVE: To assess the relationships between...

Impact of androgen deprivation therapy on mortality of prostate cancer patients with COVID-19: a propensity score-based analysis.

Infectious agents and cancer

Duarte MBO, Leal F, Argenton JLP, Carvalheira JBC.
PMID: 34823563
Infect Agent Cancer. 2021 Nov 25;16(1):66. doi: 10.1186/s13027-021-00406-y.

BACKGROUND: Previous studies hypothesized that androgen deprivation therapy (ADT) may reduce severe acute respiratory syndrome coronavirus 2 (SARS-COV2) infectivity. However, it is unknown whether there is an association between ADT and a higher survival in prostate cancer patients with...

Analysis of the circulating myeloid-derived suppressor cells during androgen deprivation therapy for prostate cancer.

IJU case reports

Kohada Y, Kaiho Y, Takeda K, Kuromoto A, Ito J, Teishima J, Nakamura Y, Kaifu T, Nakamura A, Sato M.
PMID: 34755058
IJU Case Rep. 2021 Aug 01;4(6):367-370. doi: 10.1002/iju5.12351. eCollection 2021 Nov.

INTRODUCTION: The present study showed the involvement of immunosuppressive myeloid-derived suppressor cells during the disease progression in a 69-year-old man with a prostate cancer.CASE PRESENTATION: The patient with metastatic PC (cT4N1M1ab) was initially treated with primary androgen deprivation therapy...

Current treatment of non-metastatic castration-refractory prostate cancer.

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti

Büchler T.
PMID: 34362254
Klin Onkol. 2021;34(3):185-191. doi: 10.48095/ccko2021185.

BACKGROUND: Non-metastatic castration-refractory prostate cancer (nmCRPC) is defined by increasing serum prostate specific antigen (PSA) levels despite androgen deprivation therapy in the absence of metastases on standard imaging methods including CT of the chest, abdomen and pelvis, and bone...

Androgenic Activity of Antiandrogens Predicted by Fit into DNA.

American journal of therapeutics

Steinsapir J, Mora G, Muldoon TG, Mahesh VB, Hendry LB.
PMID: 11835093
Am J Ther. 1994 Oct;1(3):236-244. doi: 10.1097/00045391-199410000-00011.

Computer modeling including graphics and energy calculations were employed for the first time to examine the stereochemical fit of antiandrogens into double-stranded DNA. In this study, we assessed the relative fit of antiandrogens in the cavity between base pairs...

Meeting report: moving upstream-evaluating adverse upstream end points for improved risk assessment and decision-making.

Environmental health perspectives

Woodruff TJ, Zeise L, Axelrad DA, Guyton KZ, Janssen S, Miller M, Miller GG, Schwartz JM, Alexeeff G, Anderson H, Birnbaum L, Bois F, Cogliano VJ, Crofton K, Euling SY, Foster PM, Germolec DR, Gray E, Hattis DB, Kyle AD, Luebke RW, Luster MI, Portier C, Rice DC, Solomon G, Vandenberg J, Zoeller RT.
PMID: 19057713
Environ Health Perspect. 2008 Nov;116(11):1568-75. doi: 10.1289/ehp.11516. Epub 2008 Jul 10.

BACKGROUND: Assessing adverse effects from environmental chemical exposure is integral to public health policies. Toxicology assays identifying early biological changes from chemical exposure are increasing our ability to evaluate links between early biological disturbances and subsequent overt downstream effects....

New Treatments for Benign Prostatic Hyperplasia: Prostatectomy and other forms of therapy.

Canadian family physician Medecin de famille canadien

Skepasts PK, Lee LM.
PMID: 21229073
Can Fam Physician. 1991 Apr;37:935-9.

Benign prostatic hyperplasia is the most common of all neoplasms. The most common treatment is prostatectomy, but other available therapies include androgen antagonists, α-adrenergic blockers, anticholinergic agents, prostate dilation with a ballon, and urethral stents. Prostatectomy is likely to...

Showing 1 to 12 of 26 entries