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Showing 1 to 12 of 39 entries
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The Journal of clinical investigation

Wolff HG, Hardy JD, Goodell H.
PMID: 16694809
J Clin Invest. 1941 Jan;20(1):63-80. doi: 10.1172/JCI101196.

No abstract available.

Effects of simultaneous repeated exposure at high levels of arsenic and malathion on hepatic drug-biotransforming enzymes in broiler chickens.

Environmental toxicology and pharmacology

Naraharisetti SB, Aggarwal M, Ranganathan V, Sarkar SN, Kataria M, Malik JK.
PMID: 21784005
Environ Toxicol Pharmacol. 2009 Sep;28(2):213-8. doi: 10.1016/j.etap.2009.04.006. Epub 2009 Apr 15.

Groundwater contamination with arsenic is a major global health concern. The organophosphorus insecticide malathion has gained significance as an environmental pollutant due to its widespread use in agriculture, grain storage, ectoparasite control and public health management. The deleterious effects...

Effects of orally applied butyrate bolus on histone acetylation and cytochrome P450 enzyme activity in the liver of chicken - a randomized controlled trial.

Nutrition & metabolism

Mátis G, Neogrády Z, Csikó G, Kulcsár A, Kenéz A, Huber K.
PMID: 23336999
Nutr Metab (Lond). 2013 Jan 22;10(1):12. doi: 10.1186/1743-7075-10-12.

BACKGROUND: Butyrate is known as histone deacetylase inhibitor, inducing histone hyperacetylation in vitro and playing a predominant role in the epigenetic regulation of gene expression and cell function. We hypothesized that butyrate, endogenously produced by intestinal microbial fermentation or...

Gender dependent effects of cigarette smoke on hepatic and pulmonary xenobiotic metabolizing enzymes in rats.

Environmental toxicology and pharmacology

Eke BC, Coban T, Vural N, Iscan M.
PMID: 21781847
Environ Toxicol Pharmacol. 1998 Jan;5(1):29-34. doi: 10.1016/s1382-6689(97)10003-5.

The adult male and female rats were exposed to cigarette smoke (CS) 5 times a day, with 1 h intervals, for 3 days in a chamber where smoke and fresh air lead alternatively and were killed 16 h after...

Lead exposure alters the drug metabolic activity and the homeostasis of essential metal ions in the lenticular system of the rat.

Environmental pollution (Barking, Essex : 1987)

Dwivedi RS.
PMID: 15093518
Environ Pollut. 1996;94(1):61-6. doi: 10.1016/s0269-7491(96)00057-7.

Potential lead exposure to the eyes as a result of the use of traditional cosmetic Kohl in Asia, Africa and the Middle East has been a subject of recent debate to the scientific community. In continuation of our earlier...

Comparison of effects of xenobiotics on extrahepatic and hepatic microsomal drug-metabolizing enzymes in mice.

Environmental toxicology and pharmacology

Huang R, Okuno H, Takasu M, Shiozaki Y, Inoue K.
PMID: 21781672
Environ Toxicol Pharmacol. 1996 Apr 15;1(2):123-30. doi: 10.1016/1382-6689(95)00018-6.

The content of microsomal protein is the same in both kidneys and small intestine, corresponding to 57% of the control value expressed as 100% in the untreated liver. The contents of P450 and cytochrome b(5), and the activity of...

Effects of a Single Large Dose of Ethanol on Tissue Ascorbic Acid, Drug-Metabolizing Enzymes in the Liver, and Serum and Liver Lipids in Rats Fed with a PCB-containing Diet.

Bioscience, biotechnology, and biochemistry

Mochizuki S, Kato K, Watanabe Y, Yoshida A.
PMID: 27316864
Biosci Biotechnol Biochem. 1993 Jan;57(1):12-6. doi: 10.1271/bbb.57.12.

The effects of a single administration of ethanol after feeding a PCB-containing diet on tissue ascorbic acid, drug-metabolizing enzymes in the liver, and serum and liver lipids of rats were investigated. Male Donryu and Wistar rats that had been...

Betulinic acid abates N-nitrosodimethylamine-induced changes in lipid metabolism, oxidative stress, and inflammation in the liver and kidney of Wistar rats.

Journal of biochemical and molecular toxicology

Adeleke GE, Adaramoye OA.
PMID: 34472159
J Biochem Mol Toxicol. 2021 Nov;35(11):e22901. doi: 10.1002/jbt.22901. Epub 2021 Sep 02.

N-nitrosamines have been linked with cancer in humans due to their presence in drinking water and diets. This study evaluated the role of betulinic acid (BA) in abating oxidative stress, inflammation, and hyperlipidemia in rats treated with N-nitrosodimethylamine (NDMA)....

Determinants of MTT reduction in rat hepatocytes.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

Perminde Rdhanjaland Jeffrey R Fry.
PMID: 23889067
Biomarkers. 1997;2(2):111-6. doi: 10.1080/135475097231832.

The determinants of reduction of the dye MTT (3-[4,5dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) in rat hepatocytes have been investigated. NADH, NADPH, and succinate were substrates for MTT reduction in rat liver homogenate, activity being greatest with NADH and least with succinate. Similar...

Evidence for singlet oxygen involvement in rat and human cytochrome P450-dependent substrate oxidations.

Drug metabolism and pharmacokinetics

Yasui H, Deo K, Ogura Y, Yoshida H, Shiraga T, Kagayama A, Sakurai H.
PMID: 15618693
Drug Metab Pharmacokinet. 2002;17(5):416-26. doi: 10.2133/dmpk.17.416.

Recently, we proposed that singlet oxygen ((1)O(2)) plays an essential role in microsomal cytochrome P450 (P450)-dependent p-hydroxylation of aniline and O-deethylation of 7-ethoxycoumarin. We then examined whether the role of (1)O(2) is general in the P450-dependent substrate oxidations. In...

Biodegradation of Green HE4B: Co-substrate effect, biotransformation enzymes and metabolite toxicity analysis.

Indian journal of microbiology

Kalme SD, Jadhav SU, Parshetti GK, Govindwar SP.
PMID: 23100822
Indian J Microbiol. 2010 Jun;50(2):156-64. doi: 10.1007/s12088-010-0001-5. Epub 2010 Mar 05.

A high exhaust reactive dye, Green HE4B (GHE4B) was 98% degraded in nutrient medium by Pseudomonas desmolyticum NCIM 2112 (pd2112) within 72 h at static condition. Decolorization time in synthetic 10 g/l molasses. Addition of 5 g/l peptone to...

Drug effects on dieldrin storage in rat tissue.

Bulletin of environmental contamination and toxicology

Street JC, Wang M, Blau AD.
PMID: 24192784
Bull Environ Contam Toxicol. 1966 Jan;1(1):6-15. doi: 10.1007/BF01684070.

Selected drugs were tested for effectiveness in reducing dieldrin retention by rats. Female rats were fed diets treated to contain 1 ppm dieldrin. The drugs were administered as feed additives or by i.p. injections. The rats were sacrificed after...

Showing 1 to 12 of 39 entries