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Isoenzyme frequencies in long-term selection lines of Drosophila melanogaster: IV. Isoenzyme frequencies of the leucine aminopeptidases (LAP) in lines selected for short and long developmental rate.

TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

Muhs HJ.
PMID: 24419997
Theor Appl Genet. 1975 Jan;46(5):215-20. doi: 10.1007/BF00289372.

1) Selection lines derived from a reference line, the continuation of an initial population which were founded by a double cross of four laboratory stocks, were selected for short (line KS and K) and long (line LS and L)...

Methodological Considerations and Comparisons of Measurement Results for Extracellular Proteolytic Enzyme Activities in Seawater.

Frontiers in microbiology

Obayashi Y, Wei Bong C, Suzuki S.
PMID: 29067013
Front Microbiol. 2017 Oct 10;8:1952. doi: 10.3389/fmicb.2017.01952. eCollection 2017.

Microbial extracellular hydrolytic enzymes that degrade organic matter in aquatic ecosystems play key roles in the biogeochemical carbon cycle. To provide linkages between hydrolytic enzyme activities and genomic or metabolomic studies in aquatic environments, reliable measurements are required for...

Spotlight on Melphalan Flufenamide: An Up-and-Coming Therapy for the Treatment of Myeloma.

Drug design, development and therapy

Morabito F, Tripepi G, Martino EA, Vigna E, Mendicino F, Morabito L, Todoerti K, Al-Janazreh H, D'Arrigo G, Canale FA, Cutrona G, Neri A, Martino M, Gentile M.
PMID: 34262262
Drug Des Devel Ther. 2021 Jul 08;15:2969-2978. doi: 10.2147/DDDT.S295215. eCollection 2021.

Despite recent therapeutic advances, multiple myeloma (MM) patients experience relapses as they become resistant to various classes and combinations of treatment. Melphalan (L-PAM) is an ageless drug. However, its use in the autologous stem cell transplantation (ASCT) setting and...

Gene Variation of Endoplasmic Reticulum Aminopeptidases 1 and 2, and Risk of Blood Pressure Progression and Incident Hypertension among 17,255 Initially Healthy Women.

International journal of genomics

Zee RYL, Rivera A, Inostroza Y, Ridker PM, Chasman DI, Romero JR.
PMID: 29850473
Int J Genomics. 2018 Apr 19;2018:2308585. doi: 10.1155/2018/2308585. eCollection 2018.

Recent studies have demonstrated the importance of endoplasmic reticulum aminopeptidase (ERAP) in blood pressure (BP) homeostasis. To date, no large prospective, genetic-epidemiological data are available on genetic variation within ERAP and hypertension risk. The association of 45 genetic variants...

Peptidases of the rumen bacterium, Prevotella ruminicola.


Wallace RJ, McKain N, Broderick GA, Rode LM, Walker ND, Newbold CJ, Kopecny J.
PMID: 16887560
Anaerobe. 1997 Feb;3(1):35-42. doi: 10.1006/anae.1996.0065.

Prevotella (formerly Bacteroides) ruminicola is a numerous rumen bacterium which plays a significant role in the metabolism of proteins and peptides in the rumen. Measurement of the hydrolysis of synthetic aminopeptidase substrates by sonicated extracts and whole cells of...

The role of dissolved organic nitrogen in a nitrate-rich agricultural stream.

Journal of environmental quality

Oviedo-Vargas D, Royer TV.
PMID: 26023984
J Environ Qual. 2015 Mar;44(2):668-75. doi: 10.2134/jeq2014.07.0314.

Agricultural activities have heavily altered the nitrogen (N) cycle in stream ecosystems draining croplands, particularly in the midwestern United States. However, our knowledge about dissolved organic N (DON) biogeochemistry in agricultural ecosystems is limited. From January 2011 to June...

The Analgesic Activity of Bestatin as a Potent APN Inhibitor.

Frontiers in neuroscience

Jia MR, Wei T, Xu WF.
PMID: 20631848
Front Neurosci. 2010 Jun 28;4:50. doi: 10.3389/fnins.2010.00050. eCollection 2010.

Bestatin, a small molecular weight dipeptide, is a potent inhibitor of various aminopeptidases as well as LTA4 hydrolase. Various physiological functions of Bestatin have been identified, viz.: (1) an immunomodifier for enhancing the proliferation of normal human bone marrow...

Distribution of Soil Extracellular Enzymatic, Microbial, and Biological Functions in the C and N-Cycle Pathways Along a Forest Altitudinal Gradient.

Frontiers in microbiology

Bayranvand M, Akbarinia M, Salehi Jouzani G, Gharechahi J, Baldrian P.
PMID: 34539590
Front Microbiol. 2021 Sep 03;12:660603. doi: 10.3389/fmicb.2021.660603. eCollection 2021.

The diverse chemical, biological, and microbial properties of litter and organic matter (OM) in forest soil along an altitudinal gradient are potentially important for nutrient cycling. In the present study, we sought to evaluate soil chemical, biological, microbial, and...

Proteome profiling of clear cell renal cell carcinoma in von Hippel-Lindau patients highlights upregulation of Xaa-Pro aminopeptidase-1, an anti-proliferative and anti-migratory exoprotease.


Drendel V, Heckelmann B, Chen CY, Weisser J, Espadas G, Schell C, Sabido E, Werner M, Jilg CA, Schilling O.
PMID: 29245961
Oncotarget. 2017 Oct 19;8(59):100066-100078. doi: 10.18632/oncotarget.21929. eCollection 2017 Nov 21.

Patients of the von Hippel-Lindau (VHL) disease frequently develop clear cell renal cell carcinoma (ccRCC). Using archived, formalin-fixed, paraffin-embedded (FFPE) samples, we sought to determine global proteome alterations that distinguish ccRCC tissue from adjacent, non-malignant kidney tissue in VHL-patients....

Evidence for conversion of N-Tyr-MIF-1 into MIF-1 by a specific brain aminopeptidase.

Neurochemistry international

Marks N, Berg MJ, Kastin AJ, Coy DH.
PMID: 20488055
Neurochem Int. 1984;6(3):347-53. doi: 10.1016/0197-0186(84)90077-9.

N-Tyr-MIF-1 (Tyr-Pro-Leu-Gly.NH(2)), an immunoreactive neuropeptide exhibiting saturable high affinity binding in rat brain was found to be converted into MIF-1 (Pro-Leu-Gly.NH(2)) by a specific brain aminopeptidase present in rat brain homogenates or cytosol, but with low activity associated with...

Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation in .


Timm J, Valente M, García-Caballero D, Wilson KS, González-Pacanowska D.
PMID: 28815215
mSphere. 2017 Aug 16;2(4). doi: 10.1128/mSphere.00226-17. eCollection 2017.

Leucine aminopeptidase (LAP) is found in all kingdoms of life and catalyzes the metal-dependent hydrolysis of the N-terminal amino acid residue of peptide or amino acyl substrates. LAPs have been shown to participate in the N-terminal processing of certain...

Is There an Interplay Between the Functional Domains of IRAP?.

Frontiers in cell and developmental biology

Vear A, Gaspari T, Thompson P, Chai SY.
PMID: 33134302
Front Cell Dev Biol. 2020 Sep 29;8:585237. doi: 10.3389/fcell.2020.585237. eCollection 2020.

As a member of the M1 family of aminopeptidases, insulin regulated aminopeptidase (IRAP) is characterized by distinct binding motifs at the active site in the C-terminal domain that mediate the catalysis of peptide substrates. However, what makes IRAP unique...

Showing 1 to 12 of 101 entries