TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik
Theor Appl Genet. 1975 Jan;46(5):215-20. doi: 10.1007/BF00289372.
1) Selection lines derived from a reference line, the continuation of an initial population which were founded by a double cross of four laboratory stocks, were selected for short (line KS and K) and long (line LS and L)...
Frontiers in microbiology
Obayashi Y, Wei Bong C, Suzuki S.
Front Microbiol. 2017 Oct 10;8:1952. doi: 10.3389/fmicb.2017.01952. eCollection 2017.
Microbial extracellular hydrolytic enzymes that degrade organic matter in aquatic ecosystems play key roles in the biogeochemical carbon cycle. To provide linkages between hydrolytic enzyme activities and genomic or metabolomic studies in aquatic environments, reliable measurements are required for...
Drug design, development and therapy
Morabito F, Tripepi G, Martino EA, Vigna E, Mendicino F, Morabito L, Todoerti K, Al-Janazreh H, D'Arrigo G, Canale FA, Cutrona G, Neri A, Martino M, Gentile M.
Drug Des Devel Ther. 2021 Jul 08;15:2969-2978. doi: 10.2147/DDDT.S295215. eCollection 2021.
Despite recent therapeutic advances, multiple myeloma (MM) patients experience relapses as they become resistant to various classes and combinations of treatment. Melphalan (L-PAM) is an ageless drug. However, its use in the autologous stem cell transplantation (ASCT) setting and...
International journal of genomics
Zee RYL, Rivera A, Inostroza Y, Ridker PM, Chasman DI, Romero JR.
Int J Genomics. 2018 Apr 19;2018:2308585. doi: 10.1155/2018/2308585. eCollection 2018.
Recent studies have demonstrated the importance of endoplasmic reticulum aminopeptidase (ERAP) in blood pressure (BP) homeostasis. To date, no large prospective, genetic-epidemiological data are available on genetic variation within ERAP and hypertension risk. The association of 45 genetic variants...
Wallace RJ, McKain N, Broderick GA, Rode LM, Walker ND, Newbold CJ, Kopecny J.
Anaerobe. 1997 Feb;3(1):35-42. doi: 10.1006/anae.1996.0065.
Prevotella (formerly Bacteroides) ruminicola is a numerous rumen bacterium which plays a significant role in the metabolism of proteins and peptides in the rumen. Measurement of the hydrolysis of synthetic aminopeptidase substrates by sonicated extracts and whole cells of...
Journal of environmental quality
Oviedo-Vargas D, Royer TV.
J Environ Qual. 2015 Mar;44(2):668-75. doi: 10.2134/jeq2014.07.0314.
Agricultural activities have heavily altered the nitrogen (N) cycle in stream ecosystems draining croplands, particularly in the midwestern United States. However, our knowledge about dissolved organic N (DON) biogeochemistry in agricultural ecosystems is limited. From January 2011 to June...
Frontiers in neuroscience
Jia MR, Wei T, Xu WF.
Front Neurosci. 2010 Jun 28;4:50. doi: 10.3389/fnins.2010.00050. eCollection 2010.
Bestatin, a small molecular weight dipeptide, is a potent inhibitor of various aminopeptidases as well as LTA4 hydrolase. Various physiological functions of Bestatin have been identified, viz.: (1) an immunomodifier for enhancing the proliferation of normal human bone marrow...
Frontiers in microbiology
Bayranvand M, Akbarinia M, Salehi Jouzani G, Gharechahi J, Baldrian P.
Front Microbiol. 2021 Sep 03;12:660603. doi: 10.3389/fmicb.2021.660603. eCollection 2021.
The diverse chemical, biological, and microbial properties of litter and organic matter (OM) in forest soil along an altitudinal gradient are potentially important for nutrient cycling. In the present study, we sought to evaluate soil chemical, biological, microbial, and...
Drendel V, Heckelmann B, Chen CY, Weisser J, Espadas G, Schell C, Sabido E, Werner M, Jilg CA, Schilling O.
Oncotarget. 2017 Oct 19;8(59):100066-100078. doi: 10.18632/oncotarget.21929. eCollection 2017 Nov 21.
Patients of the von Hippel-Lindau (VHL) disease frequently develop clear cell renal cell carcinoma (ccRCC). Using archived, formalin-fixed, paraffin-embedded (FFPE) samples, we sought to determine global proteome alterations that distinguish ccRCC tissue from adjacent, non-malignant kidney tissue in VHL-patients....
Marks N, Berg MJ, Kastin AJ, Coy DH.
Neurochem Int. 1984;6(3):347-53. doi: 10.1016/0197-0186(84)90077-9.
N-Tyr-MIF-1 (Tyr-Pro-Leu-Gly.NH(2)), an immunoreactive neuropeptide exhibiting saturable high affinity binding in rat brain was found to be converted into MIF-1 (Pro-Leu-Gly.NH(2)) by a specific brain aminopeptidase present in rat brain homogenates or cytosol, but with low activity associated with...
Timm J, Valente M, García-Caballero D, Wilson KS, González-Pacanowska D.
mSphere. 2017 Aug 16;2(4). doi: 10.1128/mSphere.00226-17. eCollection 2017.
Leucine aminopeptidase (LAP) is found in all kingdoms of life and catalyzes the metal-dependent hydrolysis of the N-terminal amino acid residue of peptide or amino acyl substrates. LAPs have been shown to participate in the N-terminal processing of certain...
Frontiers in cell and developmental biology
Vear A, Gaspari T, Thompson P, Chai SY.
Front Cell Dev Biol. 2020 Sep 29;8:585237. doi: 10.3389/fcell.2020.585237. eCollection 2020.
As a member of the M1 family of aminopeptidases, insulin regulated aminopeptidase (IRAP) is characterized by distinct binding motifs at the active site in the C-terminal domain that mediate the catalysis of peptide substrates. However, what makes IRAP unique...