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Improvement in metabolic risk factors for coronary heart disease associated with cilazapril treatment.

American journal of hypertension

Shieh SM, Sheu WH, Shen DD, Fuh MM, Jeng CY, Jeng JR, Chen YD, Reaven GM.
PMID: 1388960
Am J Hypertens. 1992 Aug;5(8):506-10. doi: 10.1093/ajh/5.8.506.

Patients with hypertension tend to be glucose intolerant, hyperinsulinemic, and dyslipedemic. Since all of these changes increase risk of coronary heart disease (CHD), it is important to know what effect antihypertensive treatment has on these variables. The current open-labelled,...

Inhibition of human renin by rat plasma. Rat angiotensinogen is a competitive inhibitor of the human renin-substrate interaction.

American journal of hypertension

Gahnem F, Sealey JE, Atlas SA, Laragh JH.
PMID: 1388958
Am J Hypertens. 1992 Aug;5(8):495-501. doi: 10.1093/ajh/5.8.495.

Human renin can cleave rat angiotensinogen, yet infusion of human renin into rats causes only a modest increase in blood pressure. We therefore investigated whether there is a factor in rat plasma which inhibits human renin activity. The addition...

Concomitant release of renin, angiotensin I, and angiotensin II during superfusion of human juxtaglomerular cell tumor.

American journal of hypertension

Fallo F, D'Agostino D, Armanini D, Caregaro L, Mantero F.
PMID: 1388967
Am J Hypertens. 1992 Aug;5(8):566-9. doi: 10.1093/ajh/5.8.566.

Increasing evidence indicates that angiotensin II can be formed by juxtaglomerular cells (JGC) and cosecreted with renin. We investigated the existence of this local renin-angiotensin system in a human JGC tumor, using an in vitro superfusion. The JGC tumor...

Platelet membrane and calcium control abnormalities in essential hypertension.

American journal of hypertension

Bühler FR, Resink TJ.
PMID: 2835965
Am J Hypertens. 1988 Jan;1(1):42-6. doi: 10.1093/ajh/1.1.42.

The mechanisms whereby intracellular calcium concentration is controlled are briefly reviewed. With the current knowledge of both calcium homeostasis and the function and properties of cellular Ca2+-target proteins/signal transduction systems, a dysfunction of cellular calcium metabolism is considered in...

Long-term effects of excess sucrose ingestion on three strains of rats.

American journal of hypertension

el Zein M, Areas JL, Preuss HG.
PMID: 2363896
Am J Hypertens. 1990 Jul;3(7):560-2. doi: 10.1093/ajh/3.7.560.

We placed groups of spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY) and a local strain of normotensive Wistar rats on 5 different diets. Our baseline diet (I) derived a near equal number of calories from sucrose, proteins and fats,...

Rat brain regional preproenkephalin A messenger RNA levels are altered in genetic hypertension.

American journal of hypertension

Hoegler DB, Sole MJ, Liew CC.
PMID: 2474307
Am J Hypertens. 1989 Jul;2(7):542-8. doi: 10.1093/ajh/2.7.542.

Considerable neuroanatomical and pharmacological evidence suggests that preproenkephalin A-derived peptides, particularly methionine-enkephalin, are involved in regulation of the cardiovascular system in both physiological and pathological states. In this study, we used a rat preproenkephalin A complementary DNA to determine...

Comparative studies of angiotensin converting enzyme inhibitors with and without the SH-radical.

American journal of hypertension

Nakagawa M, Kobayashi K, Sawada S, Toyoda T, Shirai K, Katoh K, Yamamoto K, Tsuji H, Sasaki S, Takeda K.
PMID: 1848988
Am J Hypertens. 1991 Jan;4(1):54S-55S. doi: 10.1093/ajh/4.1.54s.

This study was conducted to evaluate the effects of an SH-radical in an angiotensin converting enzyme (ACE) inhibitor on PGI2 generation, intracellular cGMP, and Ca2+ kinetics in vascular endothelial cells. In the cultured human umbilical vein endothelial cells, the...

Imidazoline receptors. A new regulatory concept in blood pressure control.

American journal of hypertension

Laragh JH.
PMID: 1596394
Am J Hypertens. 1992 Apr;5(4):45S-46S.

No abstract available.

Sites, mechanisms of action, and differentiation of calcium channel antagonists.

American journal of hypertension

Triggle DJ.
PMID: 1654937
Am J Hypertens. 1991 Jul;4(7):422S-429S. doi: 10.1093/ajh/4.7.422s.

The calcium channel antagonists are a chemically heterogeneous group of agents that includes verapamil, nifedipine, and diltiazem as first-generation agents. They owe their effectiveness to interactions at specific sites associated with a major protein of the L class of...

Long-term humoral and hemodynamic effects of celiprolol.

American journal of hypertension

Lucarini AR, Simonini N, Palmieri L, Salvetti A.
PMID: 2970852
Am J Hypertens. 1988 Jul;1(3):211S-213S. doi: 10.1093/ajh/1.3.211s.

To evaluate the humoral and hemodynamic (both systemic and renal) effects of chronic treatment with celiprolol, six out-patients with mild to moderate uncomplicated essential hypertension received placebo for 1 month and celiprolol (400 mg qid) for 6 months. At...

Pharmacokinetics of single and consecutive doses of cilazapril and its depressor effects in patients with essential hypertension.

American journal of hypertension

Shionoiri H, Gotoh E, Miyakawa T, Takasaki I, Oda H, Ueda S, Kaneko Y.
PMID: 2970854
Am J Hypertens. 1988 Jul;1(3):269S-273S. doi: 10.1093/ajh/1.3.269s.

The pharmacokinetic properties and antihypertensive effects of cilazapril, a long-acting angiotensin-converting enzyme (ACE) inhibitor, were investigated in five patients with mild to moderate essential hypertension (mean age 57 years, mean serum creatinine 1.2 mg/dL, mean glomerular filtration rate 69...

Effects of normal pregnancy on cellular cation metabolism and peripheral vascular resistance.

American journal of hypertension

Sowers JR, Zemel MB, Walsh MF, Standley PR, Zemel PC, Bronsteen RA, Kraniak J, Sokol RJ.
PMID: 2154237
Am J Hypertens. 1990 Jan;3(1):16-22. doi: 10.1093/ajh/3.1.16.

Normal pregnancy is associated with a poorly understood loss of vascular responsiveness to the pressor effects of infused angiotensin II. Since cellular cation metabolism appears to be a critical determinant of basal vascular tone and vascular reactivity, we have...

Showing 1 to 12 of 7540 entries