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Showing 1 to 12 of 75 entries
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Cardiac-targeted NADPH oxidase 4 in the adaptive cardiac remodelling of the murine heart.

Lancet (London, England)

Nabeebaccus A, Hafstad A, Eykyn T, Yin X, Brewer A, Zhang M, Mayr M, Shah A.
PMID: 26312895
Lancet. 2015 Feb 26;385:S73. doi: 10.1016/S0140-6736(15)60388-9.

BACKGROUND: The mechanisms that determine whether the heart adapts to overload stress, or fails, are poorly understood. NADPH oxidase (NOX) proteins produce reactive oxygen species (ROS) involved in redox signalling, and our recent studies have found that an increase...

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Nabeebaccus A, Hafstad A, Eykyn T, et al. Cardiac-targeted NADPH oxidase 4 in the adaptive cardiac remodelling of the murine heart. Lancet. 2015;385:S73doi: 10.1016/S0140-6736(15)60388-9.
Nabeebaccus, A., Hafstad, A., Eykyn, T., Yin, X., Brewer, A., Zhang, M., Mayr, M., & Shah, A. (2015). Cardiac-targeted NADPH oxidase 4 in the adaptive cardiac remodelling of the murine heart. Lancet (London, England), 385S73. https://doi.org/10.1016/S0140-6736(15)60388-9
Nabeebaccus, Adam, et al. "Cardiac-targeted NADPH oxidase 4 in the adaptive cardiac remodelling of the murine heart." Lancet (London, England) vol. 385 (2015): S73. doi: https://doi.org/10.1016/S0140-6736(15)60388-9
Nabeebaccus A, Hafstad A, Eykyn T, Yin X, Brewer A, Zhang M, Mayr M, Shah A. Cardiac-targeted NADPH oxidase 4 in the adaptive cardiac remodelling of the murine heart. Lancet. 2015 Feb 26;385:S73. doi: 10.1016/S0140-6736(15)60388-9. PMID: 26312895.
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Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features.

JIMD reports

Conboy E, Vairo F, Schultz M, Agre K, Ridsdale R, Deyle D, Oglesbee D, Gavrilov D, Klee EW, Lanpher B.
PMID: 29030856
JIMD Rep. 2018;40:63-69. doi: 10.1007/8904_2017_59. Epub 2017 Oct 14.

We report an 8-month-old infant with decreased consciousness after a febrile episode and reduced oral intake. He was profoundly acidotic but his lactate was normal. Serum triglycerides were markedly elevated and HDL cholesterol was very low. The urine organic...

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Conboy E, Vairo F, Schultz M, et al. Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features. JIMD Rep. 2017;40:63-69doi: 10.1007/8904_2017_59.
Conboy, E., Vairo, F., Schultz, M., Agre, K., Ridsdale, R., Deyle, D., Oglesbee, D., Gavrilov, D., Klee, E. W., & Lanpher, B. (2018). Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features. JIMD reports, 4063-69. https://doi.org/10.1007/8904_2017_59
Conboy, Erin, et al. "Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features." JIMD reports vol. 40 (2018): 63-69. doi: https://doi.org/10.1007/8904_2017_59
Conboy E, Vairo F, Schultz M, Agre K, Ridsdale R, Deyle D, Oglesbee D, Gavrilov D, Klee EW, Lanpher B. Mitochondrial 3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency: Unique Presenting Laboratory Values and a Review of Biochemical and Clinical Features. JIMD Rep. 2018;40:63-69. doi: 10.1007/8904_2017_59. Epub 2017 Oct 14. PMID: 29030856; PMCID: PMC6122033.
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Mutation analysis of methylmalonyl CoA mutase gene exon 2 in Egyptian families: Identification of 25 novel allelic variants.

Meta gene

Ghoraba DA, Mohammed MM, Zaki OK.
PMID: 25750861
Meta Gene. 2015 Feb 25;3:71-88. doi: 10.1016/j.mgene.2014.02.001. eCollection 2015 Feb.

Methylmalonic aciduria (MMA) is an autosomal recessive disorder of methylmalonate and cobalamin (cbl; vitamin B12) metabolism. It is an inborn error of organic acid metabolism which commonly results from a defect in the gene encoding the methylmalonyl-CoA mutase (MCM)...

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Ghoraba DA, Mohammed MM, Zaki OK. Mutation analysis of methylmalonyl CoA mutase gene exon 2 in Egyptian families: Identification of 25 novel allelic variants. Meta Gene. 2015;3:71-88doi: 10.1016/j.mgene.2014.02.001.
Ghoraba, D. A., Mohammed, M. M., & Zaki, O. K. (2015). Mutation analysis of methylmalonyl CoA mutase gene exon 2 in Egyptian families: Identification of 25 novel allelic variants. Meta gene, 371-88. https://doi.org/10.1016/j.mgene.2014.02.001
Ghoraba, Dina A, et al. "Mutation analysis of methylmalonyl CoA mutase gene exon 2 in Egyptian families: Identification of 25 novel allelic variants." Meta gene vol. 3 (2015): 71-88. doi: https://doi.org/10.1016/j.mgene.2014.02.001
Ghoraba DA, Mohammed MM, Zaki OK. Mutation analysis of methylmalonyl CoA mutase gene exon 2 in Egyptian families: Identification of 25 novel allelic variants. Meta Gene. 2015 Feb 25;3:71-88. doi: 10.1016/j.mgene.2014.02.001. eCollection 2015 Feb. PMID: 25750861; PMCID: PMC4349194.
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Cholinesterase-catalyzed resolution of D,L-carnitine.

Biotechnology and bioengineering

Dropsy EP, Klibanov AM.
PMID: 18553477
Biotechnol Bioeng. 1984 Aug;26(8):911-5. doi: 10.1002/bit.260260815.

An enzymatic method for the preparative resolution of racemic carnitine (whose L-isomer and its acyl-derivatives have numerous therapeutical applications) has been developed. It is based on our finding that electriceel acetylcholinesterase hydrolyzes the D- but not the L-isomer of...

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Dropsy EP, Klibanov AM. Cholinesterase-catalyzed resolution of D,L-carnitine. Biotechnol Bioeng. 1984;26(8):911-5doi: 10.1002/bit.260260815.
Dropsy, E. P., & Klibanov, A. M. (1984). Cholinesterase-catalyzed resolution of D,L-carnitine. Biotechnology and bioengineering, 26(8), 911-5. https://doi.org/10.1002/bit.260260815
Dropsy, E P, and Klibanov, A M. "Cholinesterase-catalyzed resolution of D,L-carnitine." Biotechnology and bioengineering vol. 26,8 (1984): 911-5. doi: https://doi.org/10.1002/bit.260260815
Dropsy EP, Klibanov AM. Cholinesterase-catalyzed resolution of D,L-carnitine. Biotechnol Bioeng. 1984 Aug;26(8):911-5. doi: 10.1002/bit.260260815. PMID: 18553477.
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Mediation of phorbol ester-induced oxidant generation in murine epidermal cells by protein kinase C.

Toxicology in vitro : an international journal published in association with BIBRA

Fischer SM, Baldwin JK, Jasheway DW, Patrick KE.
PMID: 20837424
Toxicol In Vitro. 1989;3(3):195-9. doi: 10.1016/0887-2333(89)90005-2.

Murine epidermal cells have previously been shown to produce an oxidant response to the mouse skin tumour promoter 12-O-tetradecanoylphorbol-13-acetate (TPA); however, the cellular source of these oxidants has not been well characterized. The demonstration that phospholipase C also elicits...

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Fischer SM, Baldwin JK, Jasheway DW, et al. Mediation of phorbol ester-induced oxidant generation in murine epidermal cells by protein kinase C. Toxicol In Vitro. 1989;3(3):195-9doi: 10.1016/0887-2333(89)90005-2.
Fischer, S. M., Baldwin, J. K., Jasheway, D. W., & Patrick, K. E. (1989). Mediation of phorbol ester-induced oxidant generation in murine epidermal cells by protein kinase C. Toxicology in vitro : an international journal published in association with BIBRA, 3(3), 195-9. https://doi.org/10.1016/0887-2333(89)90005-2
Fischer, S M, et al. "Mediation of phorbol ester-induced oxidant generation in murine epidermal cells by protein kinase C." Toxicology in vitro : an international journal published in association with BIBRA vol. 3,3 (1989): 195-9. doi: https://doi.org/10.1016/0887-2333(89)90005-2
Fischer SM, Baldwin JK, Jasheway DW, Patrick KE. Mediation of phorbol ester-induced oxidant generation in murine epidermal cells by protein kinase C. Toxicol In Vitro. 1989;3(3):195-9. doi: 10.1016/0887-2333(89)90005-2. PMID: 20837424.
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Early metabolic response to acute myocardial ischaemia in patients undergoing elective coronary angioplasty.

Open heart

Di Marino S, Viceconte N, Lembo A, Summa V, Tanzilli G, Raparelli V, Truscelli G, Mangieri E, Gaudio C, Cicero DO.
PMID: 29632675
Open Heart. 2018 Mar 10;5(1):e000709. doi: 10.1136/openhrt-2017-000709. eCollection 2018.

OBJECTIVE: Balloon-induced transient coronary ischaemia represents a model of myocardial ischaemia and reperfusion. We are interested in the very early systemic metabolic response to this event.METHODS: Blood samples of patients with stable angina (SA) were collected before and after...

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Di Marino S, Viceconte N, Lembo A, et al. Early metabolic response to acute myocardial ischaemia in patients undergoing elective coronary angioplasty. Open Heart. 2018;5(1):e000709doi: 10.1136/openhrt-2017-000709.
Di Marino, S., Viceconte, N., Lembo, A., Summa, V., Tanzilli, G., Raparelli, V., Truscelli, G., Mangieri, E., Gaudio, C., & Cicero, D. O. (2018). Early metabolic response to acute myocardial ischaemia in patients undergoing elective coronary angioplasty. Open heart, 5(1), e000709. https://doi.org/10.1136/openhrt-2017-000709
Di Marino, Sara, et al. "Early metabolic response to acute myocardial ischaemia in patients undergoing elective coronary angioplasty." Open heart vol. 5,1 (2018): e000709. doi: https://doi.org/10.1136/openhrt-2017-000709
Di Marino S, Viceconte N, Lembo A, Summa V, Tanzilli G, Raparelli V, Truscelli G, Mangieri E, Gaudio C, Cicero DO. Early metabolic response to acute myocardial ischaemia in patients undergoing elective coronary angioplasty. Open Heart. 2018 Mar 10;5(1):e000709. doi: 10.1136/openhrt-2017-000709. eCollection 2018. PMID: 29632675; PMCID: PMC5888439.
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Serum metabolomics analysis reveals increased lipid catabolism in mildly hyperbilirubinemic Gilbert's syndrome individuals.

Metabolism: clinical and experimental

Hana CA, Tran LV, Mölzer C, Müllner E, Hörmann-Wallner M, Franzke B, Tosevska A, Zöhrer PA, Doberer D, Marculescu R, Bulmer AC, Freisling H, Moazzami AA, Wagner KH.
PMID: 34653509
Metabolism. 2021 Dec;125:154913. doi: 10.1016/j.metabol.2021.154913. Epub 2021 Oct 20.

BACKGROUND: The protective role of mildly elevated bilirubin against CVD and diabetes mellitus type 2 (DMT2) is associated with a favorable lipid phenotype. As the mechanistic understanding of this protection in humans remains elusive, we aimed to assess the...

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Hana CA, Tran LV, Mölzer C, et al. Serum metabolomics analysis reveals increased lipid catabolism in mildly hyperbilirubinemic Gilbert's syndrome individuals. Metabolism. 2021;125:154913doi: 10.1016/j.metabol.2021.154913.
Hana, C. A., Tran, L. V., Mölzer, C., Müllner, E., Hörmann-Wallner, M., Franzke, B., Tosevska, A., Zöhrer, P. A., Doberer, D., Marculescu, R., Bulmer, A. C., Freisling, H., Moazzami, A. A., & Wagner, K. H. (2021). Serum metabolomics analysis reveals increased lipid catabolism in mildly hyperbilirubinemic Gilbert's syndrome individuals. Metabolism: clinical and experimental, 125154913. https://doi.org/10.1016/j.metabol.2021.154913
Hana, Claudia A, et al. "Serum metabolomics analysis reveals increased lipid catabolism in mildly hyperbilirubinemic Gilbert's syndrome individuals." Metabolism: clinical and experimental vol. 125 (2021): 154913. doi: https://doi.org/10.1016/j.metabol.2021.154913
Hana CA, Tran LV, Mölzer C, Müllner E, Hörmann-Wallner M, Franzke B, Tosevska A, Zöhrer PA, Doberer D, Marculescu R, Bulmer AC, Freisling H, Moazzami AA, Wagner KH. Serum metabolomics analysis reveals increased lipid catabolism in mildly hyperbilirubinemic Gilbert's syndrome individuals. Metabolism. 2021 Dec;125:154913. doi: 10.1016/j.metabol.2021.154913. Epub 2021 Oct 20. PMID: 34653509.
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Nuclear magnetic resonance spectroscopy to investigate the association between milk metabolites and udder quarter health status in dairy cows.

Journal of dairy science

Bobbo T, Meoni G, Niero G, Tenori L, Luchinat C, Cassandro M, Penasa M.
PMID: 34656344
J Dairy Sci. 2021 Oct 13; doi: 10.3168/jds.2021-20906. Epub 2021 Oct 13.

Nuclear magnetic resonance spectroscopy was applied to investigate the association between milk metabolome and udder quarter health status in dairy cows. Mammary gland health status was defined by combining information provided by traditional somatic cell count (SCC) and differential...

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Bobbo T, Meoni G, Niero G, et al. Nuclear magnetic resonance spectroscopy to investigate the association between milk metabolites and udder quarter health status in dairy cows. J Dairy Sci. 2021;doi: 10.3168/jds.2021-20906.
Bobbo, T., Meoni, G., Niero, G., Tenori, L., Luchinat, C., Cassandro, M., & Penasa, M. (2021). Nuclear magnetic resonance spectroscopy to investigate the association between milk metabolites and udder quarter health status in dairy cows. Journal of dairy science, . https://doi.org/10.3168/jds.2021-20906
Bobbo, T, et al. "Nuclear magnetic resonance spectroscopy to investigate the association between milk metabolites and udder quarter health status in dairy cows." Journal of dairy science vol. (2021). doi: https://doi.org/10.3168/jds.2021-20906
Bobbo T, Meoni G, Niero G, Tenori L, Luchinat C, Cassandro M, Penasa M. Nuclear magnetic resonance spectroscopy to investigate the association between milk metabolites and udder quarter health status in dairy cows. J Dairy Sci. 2021 Oct 13; doi: 10.3168/jds.2021-20906. Epub 2021 Oct 13. PMID: 34656344.
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Age and sex dependent changes of free circulating blood metabolite and lipid abundances, correlations and ratios.

The journals of gerontology. Series A, Biological sciences and medical sciences

Di Cesare F, Luchinat C, Tenori L, Saccenti E.
PMID: 34748631
J Gerontol A Biol Sci Med Sci. 2021 Nov 08; doi: 10.1093/gerona/glab335. Epub 2021 Nov 08.

In this study we investigated how the concentrations, pairwise correlations, and ratios of 202 free circulating blood metabolites and lipids vary with age in a panel of n=1882 subjects ranging from 48 to 94 years. We report a statistically...

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Di Cesare F, Luchinat C, Tenori L, et al. Age and sex dependent changes of free circulating blood metabolite and lipid abundances, correlations and ratios. J Gerontol A Biol Sci Med Sci. 2021;doi: 10.1093/gerona/glab335.
Di Cesare, F., Luchinat, C., Tenori, L., & Saccenti, E. (2021). Age and sex dependent changes of free circulating blood metabolite and lipid abundances, correlations and ratios. The journals of gerontology. Series A, Biological sciences and medical sciences, . https://doi.org/10.1093/gerona/glab335
Di Cesare, Francesca, et al. "Age and sex dependent changes of free circulating blood metabolite and lipid abundances, correlations and ratios." The journals of gerontology. Series A, Biological sciences and medical sciences vol. (2021). doi: https://doi.org/10.1093/gerona/glab335
Di Cesare F, Luchinat C, Tenori L, Saccenti E. Age and sex dependent changes of free circulating blood metabolite and lipid abundances, correlations and ratios. J Gerontol A Biol Sci Med Sci. 2021 Nov 08; doi: 10.1093/gerona/glab335. Epub 2021 Nov 08. PMID: 34748631.
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A dramatic conformational effect of multifunctional zwitterions on zeolite crystallization.

Chemical communications (Cambridge, England)

Dong L, Zhai D, Chen Z, Zheng G, Wang Y, Hong M, Yang S.
PMID: 33165479
Chem Commun (Camb). 2020 Dec 04;56(93):14693-14696. doi: 10.1039/d0cc04965d. Epub 2020 Nov 09.

Carnitine functions as a mesoporogen in LTA zeolite synthesis whereas its structural analogue acetylcarnitine acts as a crystal growth modifier. An array of experimental and theoretical studies reveal a remarkable effect of molecular conformation on the actual roles of...

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Dong L, Zhai D, Chen Z, et al. A dramatic conformational effect of multifunctional zwitterions on zeolite crystallization. Chem Commun (Camb). 2020;56(93):14693-14696doi: 10.1039/d0cc04965d.
Dong, L., Zhai, D., Chen, Z., Zheng, G., Wang, Y., Hong, M., & Yang, S. (2020). A dramatic conformational effect of multifunctional zwitterions on zeolite crystallization. Chemical communications (Cambridge, England), 56(93), 14693-14696. https://doi.org/10.1039/d0cc04965d
Dong, Lei, et al. "A dramatic conformational effect of multifunctional zwitterions on zeolite crystallization." Chemical communications (Cambridge, England) vol. 56,93 (2020): 14693-14696. doi: https://doi.org/10.1039/d0cc04965d
Dong L, Zhai D, Chen Z, Zheng G, Wang Y, Hong M, Yang S. A dramatic conformational effect of multifunctional zwitterions on zeolite crystallization. Chem Commun (Camb). 2020 Dec 04;56(93):14693-14696. doi: 10.1039/d0cc04965d. Epub 2020 Nov 09. PMID: 33165479.
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A Multivariate Metabolomics Method for Estimating Platelet Mitochondrial Oxygen Consumption Rates in Patients with Sepsis.

Metabolites

McCann MR, McHugh CE, Kirby M, Jennaro TS, Jones AE, Stringer KA, Puskarich MA.
PMID: 32252461
Metabolites. 2020 Apr 02;10(4). doi: 10.3390/metabo10040139.

BACKGROUND: Sepsis-induced alterations in mitochondrial function contribute to organ dysfunction and mortality. Measuring mitochondrial function in vital organs is neither feasible nor practical, highlighting the need for non-invasive approaches. Mitochondrial function may be reflected in the concentrations of metabolites...

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McCann MR, McHugh CE, Kirby M, et al. A Multivariate Metabolomics Method for Estimating Platelet Mitochondrial Oxygen Consumption Rates in Patients with Sepsis. Metabolites. 2020;10(4)doi: 10.3390/metabo10040139.
McCann, M. R., McHugh, C. E., Kirby, M., Jennaro, T. S., Jones, A. E., Stringer, K. A., & Puskarich, M. A. (2020). A Multivariate Metabolomics Method for Estimating Platelet Mitochondrial Oxygen Consumption Rates in Patients with Sepsis. Metabolites, 10(4), . https://doi.org/10.3390/metabo10040139
McCann, Marc R, et al. "A Multivariate Metabolomics Method for Estimating Platelet Mitochondrial Oxygen Consumption Rates in Patients with Sepsis." Metabolites vol. 10,4 (2020). doi: https://doi.org/10.3390/metabo10040139
McCann MR, McHugh CE, Kirby M, Jennaro TS, Jones AE, Stringer KA, Puskarich MA. A Multivariate Metabolomics Method for Estimating Platelet Mitochondrial Oxygen Consumption Rates in Patients with Sepsis. Metabolites. 2020 Apr 02;10(4). doi: 10.3390/metabo10040139. PMID: 32252461; PMCID: PMC7240966.
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A clinical metabolomics-based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma.

Oncology letters

Sun Y, Li S, Li J, Xiao X, Hua Z, Wang X, Yan S.
PMID: 31897184
Oncol Lett. 2020 Jan;19(1):681-690. doi: 10.3892/ol.2019.11173. Epub 2019 Dec 02.

Gastric cardia adenocarcinoma (GCA) has a high mortality rate worldwide; however, current early diagnostic methods lack efficacy. Therefore, the aim of the present study was to identify potential biomarkers for the early diagnosis of GCA. Global metabolic profiles were...

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Sun Y, Li S, Li J, et al. A clinical metabolomics-based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma. Oncol Lett. 2019;19(1):681-690doi: 10.3892/ol.2019.11173.
Sun, Y., Li, S., Li, J., Xiao, X., Hua, Z., Wang, X., & Yan, S. (2020). A clinical metabolomics-based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma. Oncology letters, 19(1), 681-690. https://doi.org/10.3892/ol.2019.11173
Sun, Yuanfang, et al. "A clinical metabolomics-based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma." Oncology letters vol. 19,1 (2020): 681-690. doi: https://doi.org/10.3892/ol.2019.11173
Sun Y, Li S, Li J, Xiao X, Hua Z, Wang X, Yan S. A clinical metabolomics-based biomarker signature as an approach for early diagnosis of gastric cardia adenocarcinoma. Oncol Lett. 2020 Jan;19(1):681-690. doi: 10.3892/ol.2019.11173. Epub 2019 Dec 02. PMID: 31897184; PMCID: PMC6924188.
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Showing 1 to 12 of 75 entries