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Showing 1 to 12 of 115 entries
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Bis-pyrimidine acetamides: design, synthesis and biological evaluation.

Chemistry Central journal

Kumar S, Lim SM, Ramasamy K, Vasudevan M, Shah SAA, Narasimhan B.
PMID: 29086907
Chem Cent J. 2017 Aug 08;11(1):80. doi: 10.1186/s13065-017-0312-2.

BACKGROUND: In the past few years, increased resistance of microorganisms towards antimicrobial agents become a serious health problem, so there is a need for the discovery of new antimicrobial agents. On the other hand, bis-pyrimidines possess various types of...

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Kumar S, Lim SM, Ramasamy K, et al. Bis-pyrimidine acetamides: design, synthesis and biological evaluation. Chem Cent J. 2017;11(1):80doi: 10.1186/s13065-017-0312-2.
Kumar, S., Lim, S. M., Ramasamy, K., Vasudevan, M., Shah, S. A. A., & Narasimhan, B. (2017). Bis-pyrimidine acetamides: design, synthesis and biological evaluation. Chemistry Central journal, 11(1), 80. https://doi.org/10.1186/s13065-017-0312-2
Kumar, Sanjiv, et al. "Bis-pyrimidine acetamides: design, synthesis and biological evaluation." Chemistry Central journal vol. 11,1 (2017): 80. doi: https://doi.org/10.1186/s13065-017-0312-2
Kumar S, Lim SM, Ramasamy K, Vasudevan M, Shah SAA, Narasimhan B. Bis-pyrimidine acetamides: design, synthesis and biological evaluation. Chem Cent J. 2017 Aug 08;11(1):80. doi: 10.1186/s13065-017-0312-2. PMID: 29086907; PMCID: PMC5548699.
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A facile deprotection of secondary acetamides.

Organic letters

Koenig SG, Vandenbossche CP, Zhao H, Mousaw P, Singh SP, Bakale RP.
PMID: 19128192
Org Lett. 2009 Jan 15;11(2):433-6. doi: 10.1021/ol802482d.

Imidoyl chlorides, generated from secondary acetamides and oxalyl chloride, can be harnessed for a selective and practical deprotection sequence. Treatment of these intermediates with 2 equiv of propylene glycol and warming enables the rapid release of amine hydrochloride salts...

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Koenig SG, Vandenbossche CP, Zhao H, et al. A facile deprotection of secondary acetamides. Org Lett. 2009;11(2):433-6doi: 10.1021/ol802482d.
Koenig, S. G., Vandenbossche, C. P., Zhao, H., Mousaw, P., Singh, S. P., & Bakale, R. P. (2009). A facile deprotection of secondary acetamides. Organic letters, 11(2), 433-6. https://doi.org/10.1021/ol802482d
Koenig, Stefan G, et al. "A facile deprotection of secondary acetamides." Organic letters vol. 11,2 (2009): 433-6. doi: https://doi.org/10.1021/ol802482d
Koenig SG, Vandenbossche CP, Zhao H, Mousaw P, Singh SP, Bakale RP. A facile deprotection of secondary acetamides. Org Lett. 2009 Jan 15;11(2):433-6. doi: 10.1021/ol802482d. PMID: 19128192.
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N-(4-Chloro-phenyl-sulfon-yl)-2,2,2-tri-methyl-acetamide.

Acta crystallographica. Section E, Structure reports online

Gowda BT, Foro S, Sowmya BP, Nirmala PG, Fuess H.
PMID: 21202911
Acta Crystallogr Sect E Struct Rep Online. 2008 Jun 19;64:o1279. doi: 10.1107/S1600536808017583.

In the crystal structure of the title compound (N4CPSTMAA), C(11)H(14)ClNO(3)S, the conformations of the N-H and C=O bonds in the amide group are anti to each other, similar to those observed in N-phenyl-sulfonyl-2,2,2-trimethyl-acetamide (NPSTMAA) and 2,2,2-trimethyl-N-(4-methyl-phenyl-sulfon-yl)acetamide (N4MPSTMAA). The bond...

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Gowda BT, Foro S, Sowmya BP, et al. N-(4-Chloro-phenyl-sulfon-yl)-2,2,2-tri-methyl-acetamide. Acta Crystallogr Sect E Struct Rep Online. 2008;64:o1279doi: 10.1107/S1600536808017583.
Gowda, B. T., Foro, S., Sowmya, B. P., Nirmala, P. G., & Fuess, H. (2008). N-(4-Chloro-phenyl-sulfon-yl)-2,2,2-tri-methyl-acetamide. Acta crystallographica. Section E, Structure reports online, 64o1279. https://doi.org/10.1107/S1600536808017583
Gowda, B Thimme, et al. "N-(4-Chloro-phenyl-sulfon-yl)-2,2,2-tri-methyl-acetamide." Acta crystallographica. Section E, Structure reports online vol. 64 (2008): o1279. doi: https://doi.org/10.1107/S1600536808017583
Gowda BT, Foro S, Sowmya BP, Nirmala PG, Fuess H. N-(4-Chloro-phenyl-sulfon-yl)-2,2,2-tri-methyl-acetamide. Acta Crystallogr Sect E Struct Rep Online. 2008 Jun 19;64:o1279. doi: 10.1107/S1600536808017583. PMID: 21202911; PMCID: PMC2961760.
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A domino synthesis of benzoquinolinamide in the presence of iodine.

Organic & biomolecular chemistry

Zeng LY, Cai C.
PMID: 20820665
Org Biomol Chem. 2010 Nov 07;8(21):4803-5. doi: 10.1039/c0ob00364f. Epub 2010 Sep 06.

The domino synthesis of benzo[f]quinolinyl and benzo[h]quinolinyl acetamides from diketene, amines, aromatic aldehydes and naphthalenamine was developed, and the catalyst iodine was found to be crucial to the reaction. The structure was deduced from the mass spectrum, (1)H NMR,...

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Zeng LY, Cai C. A domino synthesis of benzoquinolinamide in the presence of iodine. Org Biomol Chem. 2010;8(21):4803-5doi: 10.1039/c0ob00364f.
Zeng, L. Y., & Cai, C. (2010). A domino synthesis of benzoquinolinamide in the presence of iodine. Organic & biomolecular chemistry, 8(21), 4803-5. https://doi.org/10.1039/c0ob00364f
Zeng, Li-Yan, and Cai, Chun. "A domino synthesis of benzoquinolinamide in the presence of iodine." Organic & biomolecular chemistry vol. 8,21 (2010): 4803-5. doi: https://doi.org/10.1039/c0ob00364f
Zeng LY, Cai C. A domino synthesis of benzoquinolinamide in the presence of iodine. Org Biomol Chem. 2010 Nov 07;8(21):4803-5. doi: 10.1039/c0ob00364f. Epub 2010 Sep 06. PMID: 20820665.
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Radical and Heck cyclizations of diastereomeric o-haloanilide atropisomers.

Journal of the American Chemical Society

Guthrie DB, Geib SJ, Curran DP.
PMID: 21142031
J Am Chem Soc. 2011 Jan 12;133(1):115-22. doi: 10.1021/ja108795x. Epub 2010 Dec 10.

The outcomes of radical cyclizations and Heck reactions of N-(cyclohex-2-enyl)-N-(2-iodophenyl)acetamides depend critically on the configurations of the chiral axis and the stereocenter. In substrates without an ortho-methyl group, the diastereomeric precursors interconvert slowly at ambient temperatures. Cyclization of enriched...

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Guthrie DB, Geib SJ, Curran DP. Radical and Heck cyclizations of diastereomeric o-haloanilide atropisomers. J Am Chem Soc. 2010;133(1):115-22doi: 10.1021/ja108795x.
Guthrie, D. B., Geib, S. J., & Curran, D. P. (2011). Radical and Heck cyclizations of diastereomeric o-haloanilide atropisomers. Journal of the American Chemical Society, 133(1), 115-22. https://doi.org/10.1021/ja108795x
Guthrie, David B, et al. "Radical and Heck cyclizations of diastereomeric o-haloanilide atropisomers." Journal of the American Chemical Society vol. 133,1 (2011): 115-22. doi: https://doi.org/10.1021/ja108795x
Guthrie DB, Geib SJ, Curran DP. Radical and Heck cyclizations of diastereomeric o-haloanilide atropisomers. J Am Chem Soc. 2011 Jan 12;133(1):115-22. doi: 10.1021/ja108795x. Epub 2010 Dec 10. PMID: 21142031.
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Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates.

Beilstein journal of organic chemistry

Yang WY, Marrone SA, Minors N, Zorio DA, Alabugin IV.
PMID: 21804877
Beilstein J Org Chem. 2011;7:813-23. doi: 10.3762/bjoc.7.93. Epub 2011 Jun 16.

Hybrid molecules combining photoactivated aryl acetylenes and a dicationic lysine moiety cause the most efficient double-strand (ds) DNA cleavage known to date for a small molecule. In order to test the connection between the alkylating ability and the DNA-damaging...

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Yang WY, Marrone SA, Minors N, et al. Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates. Beilstein J Org Chem. 2011;7:813-23doi: 10.3762/bjoc.7.93.
Yang, W. Y., Marrone, S. A., Minors, N., Zorio, D. A., & Alabugin, I. V. (2011). Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates. Beilstein journal of organic chemistry, 7813-23. https://doi.org/10.3762/bjoc.7.93
Yang, Wang-Yong, et al. "Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates." Beilstein journal of organic chemistry vol. 7 (2011): 813-23. doi: https://doi.org/10.3762/bjoc.7.93
Yang WY, Marrone SA, Minors N, Zorio DA, Alabugin IV. Fine-tuning alkyne cycloadditions: Insights into photochemistry responsible for the double-strand DNA cleavage via structural perturbations in diaryl alkyne conjugates. Beilstein J Org Chem. 2011;7:813-23. doi: 10.3762/bjoc.7.93. Epub 2011 Jun 16. PMID: 21804877; PMCID: PMC3135214.
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Organic synthesis using (diacetoxyiodo)benzene (DIB): Unexpected and novel oxidation of 3-oxo-butanamides to 2,2-dihalo-N-phenylacetamides.

Beilstein journal of organic chemistry

Liu WB, Chen C, Zhang Q, Zhu ZB.
PMID: 22509203
Beilstein J Org Chem. 2012;8:344-8. doi: 10.3762/bjoc.8.38. Epub 2012 Mar 07.

A novel and reliable method for the direct preparation of 2,2-dihalo-N-phenylacetamides is reported. The key transformation involves the cleavage of a carbon-carbon bond in the presence of DIB and a Lewis acid as the halogen source, and thus this...

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Liu WB, Chen C, Zhang Q, et al. Organic synthesis using (diacetoxyiodo)benzene (DIB): Unexpected and novel oxidation of 3-oxo-butanamides to 2,2-dihalo-N-phenylacetamides. Beilstein J Org Chem. 2012;8:344-8doi: 10.3762/bjoc.8.38.
Liu, W. B., Chen, C., Zhang, Q., & Zhu, Z. B. (2012). Organic synthesis using (diacetoxyiodo)benzene (DIB): Unexpected and novel oxidation of 3-oxo-butanamides to 2,2-dihalo-N-phenylacetamides. Beilstein journal of organic chemistry, 8344-8. https://doi.org/10.3762/bjoc.8.38
Liu, Wei-Bing, et al. "Organic synthesis using (diacetoxyiodo)benzene (DIB): Unexpected and novel oxidation of 3-oxo-butanamides to 2,2-dihalo-N-phenylacetamides." Beilstein journal of organic chemistry vol. 8 (2012): 344-8. doi: https://doi.org/10.3762/bjoc.8.38
Liu WB, Chen C, Zhang Q, Zhu ZB. Organic synthesis using (diacetoxyiodo)benzene (DIB): Unexpected and novel oxidation of 3-oxo-butanamides to 2,2-dihalo-N-phenylacetamides. Beilstein J Org Chem. 2012;8:344-8. doi: 10.3762/bjoc.8.38. Epub 2012 Mar 07. PMID: 22509203; PMCID: PMC3326611.
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Substituted 2-[(2-Oxo-2H-[1,2,4]triazino [2,3-c]quinazolin-6-yl)thio]acetamides with Thiazole and Thiadiazole Fragments: Synthesis, Physicochemical Properties, Cytotoxicity, and Anticancer Activity.

Scientia pharmaceutica

Kovalenko SI, Nosulenko IS, Voskoboynik AY, Berest GG, Antypenko LN, Antypenko AN, Katsev AM.
PMID: 23264935
Sci Pharm. 2012 Oct-Dec;80(4):837-65. doi: 10.3797/scipharm.1208-07. Epub 2012 Oct 04.

The series of novel N-R-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamides with thiazole and thiadiazole fragments in a molecule were obtained by alkylation of potassium salts 1.1-1.4 by N-hetaryl-2-chloroacetamides and by aminolysis of activated acids 2.1-2.4 with N,N'-carbonyldiimidazole (CDI). The structures of compounds were determined...

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Kovalenko SI, Nosulenko IS, Voskoboynik AY, et al. Substituted 2-[(2-Oxo-2H-[1,2,4]triazino [2,3-c]quinazolin-6-yl)thio]acetamides with Thiazole and Thiadiazole Fragments: Synthesis, Physicochemical Properties, Cytotoxicity, and Anticancer Activity. Sci Pharm. 2012;80(4):837-65doi: 10.3797/scipharm.1208-07.
Kovalenko, S. I., Nosulenko, I. S., Voskoboynik, A. Y., Berest, G. G., Antypenko, L. N., Antypenko, A. N., & Katsev, A. M. (2012). Substituted 2-[(2-Oxo-2H-[1,2,4]triazino [2,3-c]quinazolin-6-yl)thio]acetamides with Thiazole and Thiadiazole Fragments: Synthesis, Physicochemical Properties, Cytotoxicity, and Anticancer Activity. Scientia pharmaceutica, 80(4), 837-65. https://doi.org/10.3797/scipharm.1208-07
Kovalenko, Sergey I, et al. "Substituted 2-[(2-Oxo-2H-[1,2,4]triazino [2,3-c]quinazolin-6-yl)thio]acetamides with Thiazole and Thiadiazole Fragments: Synthesis, Physicochemical Properties, Cytotoxicity, and Anticancer Activity." Scientia pharmaceutica vol. 80,4 (2012): 837-65. doi: https://doi.org/10.3797/scipharm.1208-07
Kovalenko SI, Nosulenko IS, Voskoboynik AY, Berest GG, Antypenko LN, Antypenko AN, Katsev AM. Substituted 2-[(2-Oxo-2H-[1,2,4]triazino [2,3-c]quinazolin-6-yl)thio]acetamides with Thiazole and Thiadiazole Fragments: Synthesis, Physicochemical Properties, Cytotoxicity, and Anticancer Activity. Sci Pharm. 2012 Oct-Dec;80(4):837-65. doi: 10.3797/scipharm.1208-07. Epub 2012 Oct 04. PMID: 23264935; PMCID: PMC3528059.
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Synthesis and biological evaluation of Schiff bases and azetidinones of 1-naphthol.

Journal of pharmacy & bioallied sciences

Kumar S, Kumar P, Sati N.
PMID: 22923968
J Pharm Bioallied Sci. 2012 Jul;4(3):246-9. doi: 10.4103/0975-7406.99066.

INTRODUCTION: Schiff bases and azetidinones form an important structural class possessing wide spectrum of biological activities that include antibacterial and antifungal activity. A series of Schiff's bases N'-(substituted benzylidene)-2-(naphthalen-1-yloxy) acetohydrazides (3a-f) and azetidinones N-[3-chloro-2-oxo-4-(substituted phenyl)-azetidin-1-yl]-2-(naphthalen-1-yloxy) acetamides (4a-b) were synthesized...

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Kumar S, Kumar P, Sati N. Synthesis and biological evaluation of Schiff bases and azetidinones of 1-naphthol. J Pharm Bioallied Sci. 2012;4(3):246-9doi: 10.4103/0975-7406.99066.
Kumar, S., Kumar, P., & Sati, N. (2012). Synthesis and biological evaluation of Schiff bases and azetidinones of 1-naphthol. Journal of pharmacy & bioallied sciences, 4(3), 246-9. https://doi.org/10.4103/0975-7406.99066
Kumar, Sushil, et al. "Synthesis and biological evaluation of Schiff bases and azetidinones of 1-naphthol." Journal of pharmacy & bioallied sciences vol. 4,3 (2012): 246-9. doi: https://doi.org/10.4103/0975-7406.99066
Kumar S, Kumar P, Sati N. Synthesis and biological evaluation of Schiff bases and azetidinones of 1-naphthol. J Pharm Bioallied Sci. 2012 Jul;4(3):246-9. doi: 10.4103/0975-7406.99066. PMID: 22923968; PMCID: PMC3425175.
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Recognition of N-alkyl and N-aryl acetamides by N-alkyl ammonium resorcinarene chlorides.

Chemistry (Weinheim an der Bergstrasse, Germany)

Beyeh NK, Ala-Korpi A, Cetina M, Valkonen A, Rissanen K.
PMID: 25257765
Chemistry. 2014 Nov 10;20(46):15144-50. doi: 10.1002/chem.201402533. Epub 2014 Sep 26.

N-alkyl ammonium resorcinarene chlorides are stabilized by an intricate array of intra- and intermolecular hydrogen bonds that leads to cavitand-like structures. Depending on the upper-rim substituents, self-inclusion was observed in solution and in the solid state. The self-inclusion can...

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Beyeh NK, Ala-Korpi A, Cetina M, et al. Recognition of N-alkyl and N-aryl acetamides by N-alkyl ammonium resorcinarene chlorides. Chemistry. 2014;20(46):15144-50doi: 10.1002/chem.201402533.
Beyeh, N. K., Ala-Korpi, A., Cetina, M., Valkonen, A., & Rissanen, K. (2014). Recognition of N-alkyl and N-aryl acetamides by N-alkyl ammonium resorcinarene chlorides. Chemistry (Weinheim an der Bergstrasse, Germany), 20(46), 15144-50. https://doi.org/10.1002/chem.201402533
Beyeh, N Kodiah, et al. "Recognition of N-alkyl and N-aryl acetamides by N-alkyl ammonium resorcinarene chlorides." Chemistry (Weinheim an der Bergstrasse, Germany) vol. 20,46 (2014): 15144-50. doi: https://doi.org/10.1002/chem.201402533
Beyeh NK, Ala-Korpi A, Cetina M, Valkonen A, Rissanen K. Recognition of N-alkyl and N-aryl acetamides by N-alkyl ammonium resorcinarene chlorides. Chemistry. 2014 Nov 10;20(46):15144-50. doi: 10.1002/chem.201402533. Epub 2014 Sep 26. PMID: 25257765.
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Stereospecific Nucleophilic Substitution with Arylboronic Acids as Nucleophiles in the Presence of a CONH Group.

Angewandte Chemie (International ed. in English)

Tian D, Li C, Gu G, Peng H, Zhang X, Tang W.
PMID: 29687594
Angew Chem Int Ed Engl. 2018 Jun 11;57(24):7176-7180. doi: 10.1002/anie.201712829. Epub 2018 May 09.

Stereospecific nucleophilic substitution was achieved for the first time with arylboronic acids as nucleophiles. This transition-metal-free coupling between chiral α-aryl-α-mesylated acetamides and arylboronic acids provided access to a series of chiral α,α-diaryl acetamides with excellent enantioselectivity and moderate to...

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Tian D, Li C, Gu G, et al. Stereospecific Nucleophilic Substitution with Arylboronic Acids as Nucleophiles in the Presence of a CONH Group. Angew Chem Int Ed Engl. 2018;57(24):7176-7180doi: 10.1002/anie.201712829.
Tian, D., Li, C., Gu, G., Peng, H., Zhang, X., & Tang, W. (2018). Stereospecific Nucleophilic Substitution with Arylboronic Acids as Nucleophiles in the Presence of a CONH Group. Angewandte Chemie (International ed. in English), 57(24), 7176-7180. https://doi.org/10.1002/anie.201712829
Tian, Duanshuai, et al. "Stereospecific Nucleophilic Substitution with Arylboronic Acids as Nucleophiles in the Presence of a CONH Group." Angewandte Chemie (International ed. in English) vol. 57,24 (2018): 7176-7180. doi: https://doi.org/10.1002/anie.201712829
Tian D, Li C, Gu G, Peng H, Zhang X, Tang W. Stereospecific Nucleophilic Substitution with Arylboronic Acids as Nucleophiles in the Presence of a CONH Group. Angew Chem Int Ed Engl. 2018 Jun 11;57(24):7176-7180. doi: 10.1002/anie.201712829. Epub 2018 May 09. PMID: 29687594.
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Pd-catalyzed asymmetric allylic substitution cascade using α-(pyridin-1-yl)-acetamides formed .

Chemical science

Yao K, Yuan Q, Qu X, Liu Y, Liu D, Zhang W.
PMID: 30842843
Chem Sci. 2018 Dec 04;10(6):1767-1772. doi: 10.1039/c8sc04626c. eCollection 2019 Feb 14.

A Pd-catalyzed asymmetric allylic substitution cascade reaction, using α-(pyridin-1-yl)-acetamides (formed

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Yao K, Yuan Q, Qu X, et al. Pd-catalyzed asymmetric allylic substitution cascade using α-(pyridin-1-yl)-acetamides formed . Chem Sci. 2018;10(6):1767-1772doi: 10.1039/c8sc04626c.
Yao, K., Yuan, Q., Qu, X., Liu, Y., Liu, D., & Zhang, W. (2019). Pd-catalyzed asymmetric allylic substitution cascade using α-(pyridin-1-yl)-acetamides formed . Chemical science, 10(6), 1767-1772. https://doi.org/10.1039/c8sc04626c
Yao, Kun, et al. "Pd-catalyzed asymmetric allylic substitution cascade using α-(pyridin-1-yl)-acetamides formed ." Chemical science vol. 10,6 (2019): 1767-1772. doi: https://doi.org/10.1039/c8sc04626c
Yao K, Yuan Q, Qu X, Liu Y, Liu D, Zhang W. Pd-catalyzed asymmetric allylic substitution cascade using α-(pyridin-1-yl)-acetamides formed . Chem Sci. 2018 Dec 04;10(6):1767-1772. doi: 10.1039/c8sc04626c. eCollection 2019 Feb 14. PMID: 30842843; PMCID: PMC6369409.
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