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Pharmacokinetics and tissue distribution of ketanserin in rat, rabbit and dog.


Michiels M, Monbaliu J, Meuldermans W, Hendriks R, Geerts R, Woestenborghs R, Heykants J.
PMID: 3178917
Arzneimittelforschung. 1988 Jun;38(6):775-84.

The plasma kinetics and tissue distribution of ketanserin [+)-3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)- quinazolinedione, R 41 468) were studied in the rat, rabbit and dog. The studies were performed utilizing 3H- and 14C-labelled ketanserin and appropriate techniques to measure levels of radioactivity, unchanged...

The fate of saccharin impurities: the excretion and metabolism of toluene-2-sulphonamide in man and rat.

Xenobiotica; the fate of foreign compounds in biological systems

Renwick AG, Ball LM, Corina DL, Williams RT.
PMID: 695690
Xenobiotica. 1978 Aug;8(8):461-74. doi: 10.3109/00498257809056148.

Oral doses (20 mg/kg) of [Me-14C]toluene-2-sulphonamide were rapidly eliminated by rats (92% of dose in 24 h). Most of the 14C (88%) was recovered in the urine within 7 days with litte (5%) in the faeces. Larger oral doses...

Disposition, metabolism, and excretion of the anticancer agent crisnatol in the rat.

Drug metabolism and disposition: the biological fate of chemicals

Patel DK, Woolley JL, Shcokcor JP, Johnson RL, Taylor LC, Sigel CW.
PMID: 1676660
Drug Metab Dispos. 1991 Mar-Apr;19(2):491-7.

Disposition and metabolism of crisnatol (14C-labeled), a novel antitumor agent, was examined after po and iv administration to rats. After both routes of drug administration, there was rapid elimination of the administered radioactivity in the urine (6-12% of the...

Pharmacokinetics of ciprofloxacin. 2nd communication: distribution to and elimination from tissues and organs following single or repeated administration of [14C]ciprofloxacin in albino rats.


Siefert HM, Maruhn D, Scholl H.
PMID: 3101707
Arzneimittelforschung. 1986 Oct;36(10):1503-10.

1-Cyclopropyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-[U-14C]piperazinyl)-3-quinoline carboxylic acid (ciprofloxacin, Bay o 9867; designated tradename: Ciprobay) was administered to male and to pregnant albino rats with single intravenous or oral doses of 5 or 10 mg/kg body weight and with repeated oral doses of...

The fate of nitroguanidine in the rat.

Fundamental and applied toxicology : official journal of the Society of Toxicology

Ho B, Tillotson JA, Kincannon LC, Simboli PB, Korte DW.
PMID: 3371584
Fundam Appl Toxicol. 1988 Apr;10(3):453-8. doi: 10.1016/0272-0590(88)90291-6.

The metabolism and disposition of nitroguanidine (NG), a component of military propellants and munitions, were examined in the rat. Radiolabeled nitroguanidine [( 14C]NG) was administered orally at doses of 20 and 200 mg/kg and intravenously at a dose of...

Absorption, distribution, metabolism and excretion of [14C]ebastine after a single administration in rats.


Fujii T, Matsumoto S, Amejima H, Hatoyama T, Nakao M, Kagemoto A, Tanaka K, Miyazaki H.
PMID: 7912071
Arzneimittelforschung. 1994 Apr;44(4):527-38.

Absorption, distribution, metabolism and excretion of ebastine (4'-tert-butyl-4-[4-(diphenylmethoxy)piperidino]butyrophenone, LAS-90, CAS 90729-43-4), a novel antihistamine, were investigated with 14C-labeled compound in rats after a single oral or intravenous administration, in comparison with [14C]carebastine, an active metabolite of ebastine. After intravenous...

Absorption, distribution, metabolism and excretion of [14C]ebastine after repeated oral administration in rats.


Fujii T, Tanaka K, Matsumoto S, Hatoyama T, Nomura N, Tagawa M, Miyazaki H.
PMID: 7912072
Arzneimittelforschung. 1994 Apr;44(4):538-43.

Absorption, distribution, metabolism and excretion of ebastine (4'-tert-butyl-4-[4-(diphenylmethoxy)piperidino]butyrophenone, LAS-90, CAS 90729-43-4), a new potent histamine H1-receptor antagonist, were studied with 14C-labeled compound in male rats during and after 21 consecutive daily oral administrations at a dose of 2 mg/kg/d....

Percutaneous absorption of 14C-labelled 2-chlorobenzaldehyde in rats. Metabolism and toxicokinetics.

European journal of drug metabolism and pharmacokinetics

Rietveld EC, Hoet RM, Seutter-Berlage F, Van Rossum JM.
PMID: 3243317
Eur J Drug Metab Pharmacokinet. 1988 Oct-Dec;13(4):231-40. doi: 10.1007/BF03190084.

2-Chlorobenzaldehyde might be produced when a moist skin is exposed to the riot control agent CS. CS-hydrolysis to 2-chlorobenzaldehyde and malononitrile occurs both in vitro and in vivo. No quantitative data have thus far been reported with respect to...

Pharmacokinetic profile of idazoxan in the beagle dog.

The Journal of pharmacy and pharmacology

Vallès J, Pruñonosa J, Menargues A, Nomen M, Obach R.
PMID: 2570833
J Pharm Pharmacol. 1989 Jun;41(6):384-7. doi: 10.1111/j.2042-7158.1989.tb06482.x.

The alpha 2-antagonist idazoxan (2- (2- (1,4-benzodioxanyl))-2-imidazoline) has been given intravenously and orally to five beagle dogs at 1, 3 and 10 mg kg-1 doses. Idazoxan plasma levels were determined by a HPLC method. After intravenous administration, a linear...

Absorption, distribution, metabolism and excretion of [carbonyl-14C]mosapride citrate after repeated oral administration in rats.


Matsumoto S, Tagawa M, Hatoyama T, Fujii T, Miyazaki H, Sekine Y.
PMID: 8267677
Arzneimittelforschung. 1993 Oct;43(10):1103-8.

Absorption, distribution, metabolism and excretion of mosapride citrate ((+/-)-4-amino-5-chloro-2-ethoxy-N [[4-(4-fluorobenzyl)-2-morpholinyl]methyl]benzamide citrate, AS-4370, CAS 112885-42-4), a novel gastrokinetic agent, were studied with 14C-labeled compound in male rats during and after 21 consecutive daily oral administration at a dose of 10...

Disposition and metabolism of the new hypocholesterolemic compound S-8921 in rats and dogs.


Yamaguchi T, Nakajima Y, Mizobuchi M, Inazawa K, Kanazu T, Kadono K, Ohkawa T, Iwatani K.
PMID: 9825117
Arzneimittelforschung. 1998 Oct;48(10):995-1006.

S-8921 (methyl 1-(3,4-dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimeth oxy-2- naphthoate, CAS 151165-96-7) is a novel hypocholesterolemic agent which was found to inhibit ileal Na+/bile acid cotransporter. In this report, the pharmacokinetic profile of S-8921 was studied in rats and dogs. After dosing of 14C-S-8921...

Pharmacokinetics and metabolism of the new thromboxane A2 receptor antagonist ramatroban in animals. 1st communication: absorption, concentrations in plasma, metabolism, and excretion after single administration to rats and dogs.


Boberg M, Ahr HJ, Beckermann B, Bühner K, Siefert HM, Steinke W, Wünsche C, Hirayama M.
PMID: 9296279
Arzneimittelforschung. 1997 Aug;47(8):928-38.

The absorption, concentrations in plasma, metabolism and excretion of ramatroban ((+)-(3R)-3-(4-fluorophenylsulfonamido)-1,2,3,4-tetrahydro-9- carbazolepropanoic acid, CAS 116649-85-5, BAY u 3405) have been studied following a single intravenous, oral, or intraduodenal administration of 14C-labeled or nonlabeled compound to rats and dogs (dose...

Showing 1 to 12 of 120 entries