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Similar articles for PMID: 2146310

Showing 1 to 12 of 112 entries
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Dehydroepiandrosterone: the "missing link" between hyperinsulinemia and atherosclerosis?.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Nestler JE, Clore JN, Blackard WG.
PMID: 1387859
FASEB J. 1992 Sep;6(12):3073-5. doi: 10.1096/fasebj.6.12.1387859.

A well-established epidemiologic association exists between hyperinsulinemia and macrovascular disease. However, the mechanism or mechanisms by which hyperinsulinemia promotes atherogenesis is unknown. Recent evidence indicates that the adrenal steroid dehydroepiandrosterone (DHEA) exerts multiple antiatherogenic effects and also suggests that...

Dehydroepiandrosterone sulfate (DHEA-S) and DHEA-S-like compounds in fibrocystic disease of the breast.


Chasalow FI, Blethen SL, Bradlow HL.
PMID: 2978280
Steroids. 1988 Sep;52(3):205-15. doi: 10.1016/0039-128x(88)90004-9.

We assayed Type 1 (high K+) and Type 2 (high Na+) human breast cyst fluids for DHEA-S. When an antibody specific for the 3-sulfoconjugate end of DHEA-S was used, Type 1 cyst fluids (n = 18) showed a content...

Elevated serum DHEA-S levels in association with hyperprolactinemia.

Endocrinologia japonica

Seki K, Kato K.
PMID: 6454571
Endocrinol Jpn. 1981 Feb;28(1):79-81. doi: 10.1507/endocrj1954.28.79.

Serum DHEA-S levels were significantly higher in women with hyperprolactinemia than in normal women during the early follicular phase. When comparison was made of serum DHEA-S levels in hyper-and normoprolactinemic patients with secondary amenorrhea due to hypothalamic-pituitary failure, serum...

Dehydroepiandrosterone sulfate, incidence of myocardial infarction, and extent of atherosclerosis in men.


LaCroix AZ, Yano K, Reed DM.
PMID: 1423966
Circulation. 1992 Nov;86(5):1529-35. doi: 10.1161/01.cir.86.5.1529.

BACKGROUND: Antiatherogenic effects of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) have been suspected for more than 30 years, yet the available evidence to support or refute such effects in humans is inconclusive. The hypothesis has not been adequately tested...

A prospective study of dehydroepiandrosterone sulfate, mortality, and cardiovascular disease.

The New England journal of medicine

Barrett-Connor E, Khaw KT, Yen SS.
PMID: 2946952
N Engl J Med. 1986 Dec 11;315(24):1519-24. doi: 10.1056/NEJM198612113152405.

It has been postulated that dehydroepiandrosterone (DHEA) and its sulfate ester, dehydroepiandrosterone sulfate (DHEAS), the major secretory products of the human adrenal gland, may be discriminators of life expectancy and aging. We examined the relation of base-line circulating DHEAS...

The effect of phenytoin and carbamazepine on serum dehydroepiandrosterone sulfate in men and women who have partial seizures with temporal lobe involvement.

The Journal of clinical endocrinology and metabolism

Levesque LA, Herzog AG, Seibel MM.
PMID: 2940256
J Clin Endocrinol Metab. 1986 Jul;63(1):243-5. doi: 10.1210/jcem-63-1-243.

In a study of 16 men and 55 women with temporal lobe epilepsy (TLE), we found that the serum dehydroepiandrosterone sulfate (DHEA-S) level was significantly lower (P less than 0.05) in patients who were treated with phenytoin (mean +/-...

Do DHEA/DHEAS play a protective role in coronary heart disease?.

Physiological research

Porsová-Dutoit I, Sulcová J, Stárka L.
PMID: 10984071
Physiol Res. 2000;49:S43-56.

Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone-sulfate (DHEAS), the major androgens secreted by human adrenal glands, were suggested to play a protective role in the pathogenesis of atherosclerosis and coronary heart disease. On the basis of a critical review of all existing...

Lack of effect of exercise training on dehydroepiandrosterone-sulfate.

The American journal of the medical sciences

Milani RV, Lavie CJ, Barbee RW, Littman AB.
PMID: 7503104
Am J Med Sci. 1995 Dec;310(6):242-6.

Although functions of dehydroepiandrosterone (DHEA) and its sulfate ester are unknown, investigators have found an inverse relation between DHEA-sulfate levels and coronary artery disease, suggesting its importance as an inverse coronary risk factor. In previous studies, where behavioral therapy...

Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: contribution of the DHEAge Study to a sociobiomedical issue.

Proceedings of the National Academy of Sciences of the United States of America

Baulieu EE, Thomas G, Legrain S, Lahlou N, Roger M, Debuire B, Faucounau V, Girard L, Hervy MP, Latour F, Leaud MC, Mokrane A, Pitti-Ferrandi H, Trivalle C, de Lacharrière O, Nouveau S, Rakoto-Arison B, Souberbielle JC, Raison J, Le Bouc Y, Raynaud A, Girerd X, Forette F.
PMID: 10760294
Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4279-84. doi: 10.1073/pnas.97.8.4279.

The secretion and the blood levels of the adrenal steroid dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) decrease profoundly with age, and the question is posed whether administration of the steroid to compensate for the decline counteracts defects associated...

[Dehydroepiandrosterone therapy in men with angiographically verified coronary heart disease: the effects on plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator (tPA) and fibrinogen plasma concentrations].

Endokrynologia Polska

Rabijewski M, Zgliczyński W.
PMID: 17940987
Endokrynol Pol. 2007 May-Jun;58(3):213-9.

INTRODUCTION: The aim of this study was to analyze the influence of DHEA therapy on fibrinogen, plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) plasma concentrations in men with decreased serum DHEA-S levels and angiographically verified coronary heart...

Decreased dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) concentrations in plasma of Alzheimer's disease (AD) patients.

Archives of gerontology and geriatrics

Aldred S, Mecocci P.
PMID: 19665809
Arch Gerontol Geriatr. 2010 Jul-Aug;51(1):e16-8. doi: 10.1016/j.archger.2009.07.001. Epub 2009 Aug 08.

DHEA is secreted by the adrenal cortex and is also a neurosteroid. Its sulfate (DHEAS) is the most abundant steroid in circulation. The levels of both are seen to decline in concentration with age. Evidence is available for altered...

Wide distribution of the serum dehydroepiandrosterone and sex steroid levels in postmenopausal women: role of the ovary?.

Menopause (New York, N.Y.)

Labrie F, Martel C, Balser J.
PMID: 20683211
Menopause. 2011 Jan;18(1):30-43. doi: 10.1097/gme.0b013e3181e195a6.

OBJECTIVE: Because the exclusive source of sex steroids (at least estrogens) after menopause is recognized to be dehydroepiandrosterone (DHEA), this study examines the interindividual variability of serum DHEA and its metabolites as well as the contribution of the ovary...

Showing 1 to 12 of 112 entries