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Similar articles for PMID: 1462898

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Is adenosine 5'-triphosphate derangement or free-radical-mediated injury the major cause of ventricular dysfunction during reperfusion? Role of adenine nucleoside transport in myocardial reperfusion injury.


Abd-Elfattah AS, Jessen ME, Hanan SA, Tuchy G, Wechsler AS.
PMID: 2225426
Circulation. 1990 Nov;82(5):IV341-50.

The aim of this study was to determine the dual role of ATP as an energy substrate and as a major source of oxygen-derived free-radical-mediated reperfusion injury by using adenine nucleoside blocker, p-nitrobenzylthioinosine (NBMPR), and adenosine deaminase inhibitor, erythro-9-(2-hydroxy-3-nonyl)adenine...

Effects of postischemic left ventricular pressure-volume unloading on contractile recovery and myocardial blood flow in the regionally stunned canine heart.

The Journal of thoracic and cardiovascular surgery

Nicolosi AC, Markley JG, Olinger GN.
PMID: 10384201
J Thorac Cardiovasc Surg. 1999 Jul;118(1):181-8. doi: 10.1016/S0022-5223(99)70157-1.

OBJECTIVE: Myocardial stunning remains a clinical problem without definitive therapy. This study tested the hypothesis that mechanical therapy with a ventricular assist device would accelerate recovery of contractility in stunned myocardium by increasing the postischemic myocardial blood flow.METHODS: Regional...

Effects of delayed preconditioning on myocardial regional contractility during repeated episodes of low-flow ischaemia in anaesthetized dogs: possible role of nitric oxide.

Clinical science (London, England : 1979)

Szigeti Z, Simon K, Parratt JR, Végh A.
PMID: 14556644
Clin Sci (Lond). 2004 Feb;106(2):201-13. doi: 10.1042/CS20030290.

The effect of cardiac pacing on repeated low-flow ischaemia-induced changes in regional myocardial segmental contractility, and the role in these changes of nitric oxide, were investigated in anaesthetized dogs. Dogs were instrumented for cardiac pacing (pacing electrode in the...

Positive end-expiratory pressure does not compromise myocardial contractility in myocardial ischemia/reperfusion.

Shock (Augusta, Ga.)

Kubitz JC, Annecke T, Hinkel R, Reuter DA, Kronas N, Forkl S, Boekstegers P, Goetz AE, Kemming GI.
PMID: 17505303
Shock. 2007 Jun;27(6):638-43. doi: 10.1097/01.shk.0000246906.32519.8e.

Therapy for severe myocardial ischemia/reperfusion sometimes necessitates intermittent positive pressure ventilation, which may impair left ventricular function by reduction of ventricular loading. It is unknown today whether positive airway pressure also affects contractile force after myocardial ischemia/reperfusion. The authors...

Evaluation of regional load in acute ischemia by three-dimensional curvatures analysis of the left ventricle.

Annals of biomedical engineering

Lessick J, Sideman S, Azhari H, Shapiro E, Weiss JL, Beyar R.
PMID: 8484563
Ann Biomed Eng. 1993 Mar-Apr;21(2):147-61. doi: 10.1007/BF02367610.

Geometric remodeling of the left ventricule (LV) following myocardial infarction and ischemic insult is associated with myocardial load redistribution. Regional curvatures based on 3-D reconstructions of the LV are used to calculate the regional loads. The technique uses surface...

Endothelin-1 exacerbates diastolic stunning in conscious dogs.

The American journal of physiology

Hayashida W, Donckier J, van Mechelen H, Stoleru L, Pouleur H.
PMID: 8238581
Am J Physiol. 1993 Nov;265(5):H1688-95. doi: 10.1152/ajpheart.1993.265.5.H1688.

The purpose of this study was to examine the effects of endothelin-1 (ET-1) on "diastolic stunning" in the postischemic myocardium. In 14 conscious dogs receiving either placebo (n = 7) or ET-1 (2.5 ng.kg-1.min-1, n = 7), left ventricular...

The effects of nifedipine on myocardial blood flow and contraction during ischemia in the dog.


Weintraub WS, Hattori S, Agarwal JB, Bodenheimer MM, Banka VS, Helfant RH.
PMID: 7053288
Circulation. 1982 Jan;65(1):49-53. doi: 10.1161/01.cir.65.1.49.

Nifedipine has been proposed as an agent to preserve viability and function of ischemic myocardium. We studied 23 open-chest dogs that underwent carotid-to-left anterior coronary artery perfusion with flow probe and perfusion pressure monitoring. Segment length was measured with...

Recovery of myocardial function after repetitive episodes of reversible ischemia.

The American journal of physiology

Gall SA, Maier GW, Glower DD, Gaynor JW, Cobb FR, Sabiston DC, Rankin JS.
PMID: 8476090
Am J Physiol. 1993 Apr;264(4):H1130-8. doi: 10.1152/ajpheart.1993.264.4.H1130.

The question of whether recovery of regional myocardial function after repetitive, reversible ischemia differs from recovery after a single episode of myocardial ischemia remains controversial. Therefore, eight conscious dogs were instrumented with ultrasonic dimension transducers and left ventricular micromanometers....

Increased release of NO during ischemia reduces myocardial contractility and improves metabolic dysfunction.


Node K, Kitakaze M, Kosaka H, Komamura K, Minamino T, Inoue M, Tada M, Hori M, Kamada T.
PMID: 8548910
Circulation. 1996 Jan 15;93(2):356-64. doi: 10.1161/01.cir.93.2.356.

BACKGROUND: We have reported that myocardial ischemia increases nitric oxide (NO) production. Several lines of evidence suggest that NO reduces myocardial contraction. Therefore, we tested whether endogenous NO decreases the inotropic response of the ischemic myocardium and whether endogenous...

Augmentation of contraction in remote nonischemic zone during acute ischemia.

The American journal of physiology

Noma S, Askenase AD, Weintraub WS, Klein LW, Agarwal JB, Helfant RH.
PMID: 3407791
Am J Physiol. 1988 Aug;255(2):H301-10. doi: 10.1152/ajpheart.1988.255.2.H301.

We studied how left ventricular loading conditions and the size of the ischemic zone affect regional segmental shortening (% delta L) in ischemic (IZ) and remote nonischemic zones (NZ) after acute coronary occlusion. Distal and proximal portions of the...

Left ventricular asynchrony: an indicator of regional myocardial dysfunction.

American heart journal

Ehring T, Heusch G.
PMID: 2239657
Am Heart J. 1990 Nov;120(5):1047-57. doi: 10.1016/0002-8703(90)90116-f.

There is a marked heterogeneity of myocardial wall thickening within the left ventricle and among different individuals. It is therefore difficult to detect regional myocardial dysfunction from absolute values of systolic wall thickening. We tested whether the extent of...

Canine end-systolic pressure-length relationships: depressed by diltiazem, invalidated by ischemia.

Journal of cardiothoracic and vascular anesthesia

Goldberg AH, Diedericks J, Hopwood MB, Foëx P.
PMID: 1421071
J Cardiothorac Vasc Anesth. 1992 Oct;6(5):593-9. doi: 10.1016/1053-0770(92)90103-e.

This study was designed to determine whether the end-systolic pressure-length relationship (ESPLR) reflects changes in regional contractility during the imposition of graded ischemia, and whether it is modified by diltiazem during propofol anesthesia. Seven beagles were anesthetized and instrumented...

Showing 1 to 12 of 73 entries