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Showing 1 to 12 of 132 entries
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Measurement of free drug in phase I: is it useful?.

Fundamental & clinical pharmacology

Barré J, Riant P, Tillement JP.
PMID: 2093625
Fundam Clin Pharmacol. 1990;4:141s-150s. doi: 10.1111/j.1472-8206.1990.tb00072.x.

Early investigation of protein binding of a new drug is mandatory. The following questions have to be answered: is unbound fraction constant over tested concentrations? Which proteins are involved? What are the binding parameters? Can the drug compete with...

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Barré J, Riant P, Tillement JP. Measurement of free drug in phase I: is it useful?. Fundam Clin Pharmacol. 1990;4:141s-150sdoi: 10.1111/j.1472-8206.1990.tb00072.x.
Barré, J., Riant, P., & Tillement, J. P. (1990). Measurement of free drug in phase I: is it useful?. Fundamental & clinical pharmacology, 4141s-150s. https://doi.org/10.1111/j.1472-8206.1990.tb00072.x
Barré, J, et al. "Measurement of free drug in phase I: is it useful?." Fundamental & clinical pharmacology vol. 4 (1990): 141s-150s. doi: https://doi.org/10.1111/j.1472-8206.1990.tb00072.x
Barré J, Riant P, Tillement JP. Measurement of free drug in phase I: is it useful?. Fundam Clin Pharmacol. 1990;4:141s-150s. doi: 10.1111/j.1472-8206.1990.tb00072.x. PMID: 2093625.
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The influence of food on the absorption and metabolism of drugs: an update.

European journal of drug metabolism and pharmacokinetics

Williams L, Hill DP, Davis JA, Lowenthal DT.
PMID: 8980916
Eur J Drug Metab Pharmacokinet. 1996 Jul-Sep;21(3):201-11. doi: 10.1007/BF03189714.

Food-drug interactions can lead to a loss of therapeutic efficacy or toxic effects of drug therapy. Generally, the effect of food on drugs results in a reduction in the drug's bioavailability; however, food can also alter drug clearance. The...

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Williams L, Hill DP, Davis JA, et al. The influence of food on the absorption and metabolism of drugs: an update. Eur J Drug Metab Pharmacokinet. 1996;21(3):201-11doi: 10.1007/BF03189714.
Williams, L., Hill, D. P., Davis, J. A., & Lowenthal, D. T. (1996). The influence of food on the absorption and metabolism of drugs: an update. European journal of drug metabolism and pharmacokinetics, 21(3), 201-11. https://doi.org/10.1007/BF03189714
Williams, L, et al. "The influence of food on the absorption and metabolism of drugs: an update." European journal of drug metabolism and pharmacokinetics vol. 21,3 (1996): 201-11. doi: https://doi.org/10.1007/BF03189714
Williams L, Hill DP, Davis JA, Lowenthal DT. The influence of food on the absorption and metabolism of drugs: an update. Eur J Drug Metab Pharmacokinet. 1996 Jul-Sep;21(3):201-11. doi: 10.1007/BF03189714. PMID: 8980916.
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For medicinal purposes.

Nature

Petsko GA.
PMID: 8895592
Nature. 1996 Nov 07;384(6604):7-9. doi: 10.1038/384007a0.

Developments in techniques of pharmaceutical chemistry are poised to revolutionize the design of drugs beyond previous expectations. But what are our current expectations and what does the future hold?

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Petsko GA. For medicinal purposes. Nature. 1996;384(6604):7-9doi: 10.1038/384007a0.
Petsko, G. A. (1996). For medicinal purposes. Nature, 384(6604), 7-9. https://doi.org/10.1038/384007a0
Petsko, G A. "For medicinal purposes." Nature vol. 384,6604 (1996): 7-9. doi: https://doi.org/10.1038/384007a0
Petsko GA. For medicinal purposes. Nature. 1996 Nov 07;384(6604):7-9. doi: 10.1038/384007a0. PMID: 8895592.
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Early ADME in support of drug discovery: the role of metabolic stability studies.

Current drug metabolism

Thompson TN.
PMID: 11465046
Curr Drug Metab. 2000 Nov;1(3):215-41. doi: 10.2174/1389200003339018.

The area of Drug Discovery has undergone an amazing evolution in the past decade. This evolution is typified by the development of automated combinatorial synthesis and high throughput pharmacological testing. This, in turn, has lead to the ability to...

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Thompson TN. Early ADME in support of drug discovery: the role of metabolic stability studies. Curr Drug Metab. 2000;1(3):215-41doi: 10.2174/1389200003339018.
Thompson, T. N. (2000). Early ADME in support of drug discovery: the role of metabolic stability studies. Current drug metabolism, 1(3), 215-41. https://doi.org/10.2174/1389200003339018
Thompson, T N. "Early ADME in support of drug discovery: the role of metabolic stability studies." Current drug metabolism vol. 1,3 (2000): 215-41. doi: https://doi.org/10.2174/1389200003339018
Thompson TN. Early ADME in support of drug discovery: the role of metabolic stability studies. Curr Drug Metab. 2000 Nov;1(3):215-41. doi: 10.2174/1389200003339018. PMID: 11465046.
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Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery.

Current topics in medicinal chemistry

Yan Z, Caldwell GW.
PMID: 11899105
Curr Top Med Chem. 2001 Nov;1(5):403-25. doi: 10.2174/1568026013395001.

To reduce the high attrition rates of NCEs in preclinical and clinical development uncovering pharmacokinetics, toxicokinetics, drug metabolism, and drug-drug interactions early in drug discovery would be highly valuable. There have been many in vitro screens developed for these...

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Yan Z, Caldwell GW. Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery. Curr Top Med Chem. 2001;1(5):403-25doi: 10.2174/1568026013395001.
Yan, Z., & Caldwell, G. W. (2001). Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery. Current topics in medicinal chemistry, 1(5), 403-25. https://doi.org/10.2174/1568026013395001
Yan, Z, and Caldwell, G W. "Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery." Current topics in medicinal chemistry vol. 1,5 (2001): 403-25. doi: https://doi.org/10.2174/1568026013395001
Yan Z, Caldwell GW. Metabolism profiling, and cytochrome P450 inhibition & induction in drug discovery. Curr Top Med Chem. 2001 Nov;1(5):403-25. doi: 10.2174/1568026013395001. PMID: 11899105.
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The long, hard road: drug metabolism in the lifetime of the DMDG.

Xenobiotica; the fate of foreign compounds in biological systems

Smith DA.
PMID: 11569522
Xenobiotica. 2001 Aug-Sep;31(8):459-67. doi: 10.1080/00498250110052742.

No abstract available.

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Smith DA. The long, hard road: drug metabolism in the lifetime of the DMDG. Xenobiotica. 2001;31(8):459-67doi: 10.1080/00498250110052742.
Smith, D. A. (2001). The long, hard road: drug metabolism in the lifetime of the DMDG. Xenobiotica; the fate of foreign compounds in biological systems, 31(8), 459-67. https://doi.org/10.1080/00498250110052742
Smith, D A. "The long, hard road: drug metabolism in the lifetime of the DMDG." Xenobiotica; the fate of foreign compounds in biological systems vol. 31,8 (2001): 459-67. doi: https://doi.org/10.1080/00498250110052742
Smith DA. The long, hard road: drug metabolism in the lifetime of the DMDG. Xenobiotica. 2001 Aug-Sep;31(8):459-67. doi: 10.1080/00498250110052742. PMID: 11569522.
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Do drug metabolism and pharmacokinetic departments make any contribution to drug discovery?.

Clinical pharmacokinetics

Smith D, Schmid E, Jones B.
PMID: 12403640
Clin Pharmacokinet. 2002;41(13):1005-19. doi: 10.2165/00003088-200241130-00001.

The alignment of drug metabolism and pharmacokinetic departments with drug discovery has not produced a radical improvement in the pharmacokinetic properties of new chemical entities. The reason for this is complex, reflecting in part the difficulty of combining potency,...

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Smith D, Schmid E, Jones B. Do drug metabolism and pharmacokinetic departments make any contribution to drug discovery?. Clin Pharmacokinet. 2002;41(13):1005-19doi: 10.2165/00003088-200241130-00001.
Smith, D., Schmid, E., & Jones, B. (2002). Do drug metabolism and pharmacokinetic departments make any contribution to drug discovery?. Clinical pharmacokinetics, 41(13), 1005-19. https://doi.org/10.2165/00003088-200241130-00001
Smith, Dennis, et al. "Do drug metabolism and pharmacokinetic departments make any contribution to drug discovery?." Clinical pharmacokinetics vol. 41,13 (2002): 1005-19. doi: https://doi.org/10.2165/00003088-200241130-00001
Smith D, Schmid E, Jones B. Do drug metabolism and pharmacokinetic departments make any contribution to drug discovery?. Clin Pharmacokinet. 2002;41(13):1005-19. doi: 10.2165/00003088-200241130-00001. PMID: 12403640.
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Drug metabolism and pharmacokinetics in drug discovery.

Current opinion in drug discovery & development

Roberts SA.
PMID: 12613278
Curr Opin Drug Discov Devel. 2003 Jan;6(1):66-80.

The discovery and development of new drugs seems to be an inefficient process, since too few new chemical entities (NCEs) successfully make it to the market. Because one of the main reasons for failure in development is thought to...

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Roberts SA. Drug metabolism and pharmacokinetics in drug discovery. Curr Opin Drug Discov Devel. 2003;6(1):66-80
Roberts, S. A. (2003). Drug metabolism and pharmacokinetics in drug discovery. Current opinion in drug discovery & development, 6(1), 66-80.
Roberts, Simon A. "Drug metabolism and pharmacokinetics in drug discovery." Current opinion in drug discovery & development vol. 6,1 (2003): 66-80.
Roberts SA. Drug metabolism and pharmacokinetics in drug discovery. Curr Opin Drug Discov Devel. 2003 Jan;6(1):66-80. PMID: 12613278.
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In Silico and Ex silico ADME approaches for drug discovery.

Current topics in medicinal chemistry

Darvas F, Keseru G, Papp A, Dormán G, Urge L, Krajcsi P.
PMID: 12470281
Curr Top Med Chem. 2002 Dec;2(12):1287-304. doi: 10.2174/1568026023392841.

The high attrition rate of drug candidates during clinical trials for poor pharmacokinetic and metabolic properties has created a need to do these studies as early as it is possible during the drug discovery process. In addition the most...

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Darvas F, Keseru G, Papp A, et al. In Silico and Ex silico ADME approaches for drug discovery. Curr Top Med Chem. 2002;2(12):1287-304doi: 10.2174/1568026023392841.
Darvas, F., Keseru, G., Papp, A., Dormán, G., Urge, L., & Krajcsi, P. (2002). In Silico and Ex silico ADME approaches for drug discovery. Current topics in medicinal chemistry, 2(12), 1287-304. https://doi.org/10.2174/1568026023392841
Darvas, Ferenc, et al. "In Silico and Ex silico ADME approaches for drug discovery." Current topics in medicinal chemistry vol. 2,12 (2002): 1287-304. doi: https://doi.org/10.2174/1568026023392841
Darvas F, Keseru G, Papp A, Dormán G, Urge L, Krajcsi P. In Silico and Ex silico ADME approaches for drug discovery. Curr Top Med Chem. 2002 Dec;2(12):1287-304. doi: 10.2174/1568026023392841. PMID: 12470281.
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Computational approaches to the understanding of ADMET properties and problems.

Drug discovery today

Modi S.
PMID: 12867147
Drug Discov Today. 2003 Jul 15;8(14):621-3. doi: 10.1016/s1359-6446(03)02739-9.

No abstract available.

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Modi S. Computational approaches to the understanding of ADMET properties and problems. Drug Discov Today. 2003;8(14):621-3doi: 10.1016/s1359-6446(03)02739-9.
Modi, S. (2003). Computational approaches to the understanding of ADMET properties and problems. Drug discovery today, 8(14), 621-3. https://doi.org/10.1016/s1359-6446(03)02739-9
Modi, Sandeep. "Computational approaches to the understanding of ADMET properties and problems." Drug discovery today vol. 8,14 (2003): 621-3. doi: https://doi.org/10.1016/s1359-6446(03)02739-9
Modi S. Computational approaches to the understanding of ADMET properties and problems. Drug Discov Today. 2003 Jul 15;8(14):621-3. doi: 10.1016/s1359-6446(03)02739-9. PMID: 12867147.
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Rho Chi lecture. Pharmaceutical sciences in the next millennium.

The Annals of pharmacotherapy

Triggle DJ.
PMID: 10084422
Ann Pharmacother. 1999 Feb;33(2):241-6. doi: 10.1345/aph.18337.

Even a cursory survey of this article suggests that the pharmaceutical sciences are being rapidly transformed under the influence of both the new technologies and sciences and the economic imperatives. Of particular importance are scientific and technological advances that...

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Triggle DJ. Rho Chi lecture. Pharmaceutical sciences in the next millennium. Ann Pharmacother. 1999;33(2):241-6doi: 10.1345/aph.18337.
Triggle, D. J. (1999). Rho Chi lecture. Pharmaceutical sciences in the next millennium. The Annals of pharmacotherapy, 33(2), 241-6. https://doi.org/10.1345/aph.18337
Triggle, D J. "Rho Chi lecture. Pharmaceutical sciences in the next millennium." The Annals of pharmacotherapy vol. 33,2 (1999): 241-6. doi: https://doi.org/10.1345/aph.18337
Triggle DJ. Rho Chi lecture. Pharmaceutical sciences in the next millennium. Ann Pharmacother. 1999 Feb;33(2):241-6. doi: 10.1345/aph.18337. PMID: 10084422.
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Applications of protein arrays for small molecule drug discovery and characterization.

Biotechnology & genetic engineering reviews

Michaud GA, Salcius M, Zhou F, Papov VV, Merkel J, Murtha M, Predki P, Schweitzer B.
PMID: 18476332
Biotechnol Genet Eng Rev. 2006;22:197-211. doi: 10.1080/02648725.2006.10648071.

No abstract available.

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Michaud GA, Salcius M, Zhou F, et al. Applications of protein arrays for small molecule drug discovery and characterization. Biotechnol Genet Eng Rev. 2006;22:197-211doi: 10.1080/02648725.2006.10648071.
Michaud, G. A., Salcius, M., Zhou, F., Papov, V. V., Merkel, J., Murtha, M., Predki, P., & Schweitzer, B. (2006). Applications of protein arrays for small molecule drug discovery and characterization. Biotechnology & genetic engineering reviews, 22197-211. https://doi.org/10.1080/02648725.2006.10648071
Michaud, Gregory A, et al. "Applications of protein arrays for small molecule drug discovery and characterization." Biotechnology & genetic engineering reviews vol. 22 (2006): 197-211. doi: https://doi.org/10.1080/02648725.2006.10648071
Michaud GA, Salcius M, Zhou F, Papov VV, Merkel J, Murtha M, Predki P, Schweitzer B. Applications of protein arrays for small molecule drug discovery and characterization. Biotechnol Genet Eng Rev. 2006;22:197-211. doi: 10.1080/02648725.2006.10648071. PMID: 18476332.
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Showing 1 to 12 of 132 entries